About This Cover
Cover photograph (Copyright © 2009, American Society for Microbiology. All Rights Reserved.): Glycogen synthase kinase 3β (GSK3β) controls dMyc protein expression in vivo. Shown is a pseudocolorized montage of photos from Drosophila imaginal discs in which flip-out clones have been induced to overexpress green fluorescent protein alone (top row) or together with dMyc (second and third rows), GSK3β alone (fourth row), or dMyc together with GSK3β (fifth and sixth rows). Staining with antibodies against dMyc protein (red in third and sixth rows) shows how dMyc protein level is reduced in the presence of GSK3β, indicating that this kinase is responsible for the degradation of dMyc. Consistent with this effect, we found that coexpression of dMyc with GSK3β reduces the growth advantage of clones overexpressing dMyc alone, further confirming that overexpression of GSK3β reduces dMyc protein expression. (See related article on p. 3424.)
[Table of Contents]
Copyright © 2009 by the American Society for Microbiology. For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»