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Research Articles

  • Open Access
    A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit
    Research Article
    A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit

    The telomerase ribonucleoprotein (RNP) counters the chromosome end replication problem, completing genome replication to prevent cellular senescence in yeast, humans, and most other eukaryotes. The telomerase RNP core enzyme is composed of a dedicated RNA subunit and a reverse transcriptase (telomerase reverse transcriptase [TERT]). Although the majority of the 1,157-nucleotide (nt)...

    Melissa A. Mefford, Evan P. Hass, David C. Zappulla
  • WD Repeat Domain 77 Protein Regulates Translation of E2F1 and E2F3 mRNA
    Research Article | Spotlight
    WD Repeat Domain 77 Protein Regulates Translation of E2F1 and E2F3 mRNA

    WD repeat domain 77 protein (WDR77) is required for cellular proliferation of lung and prostate epithelial cells during earlier stages of development and is reactivated during prostate and lung tumorigenesis. WDR77 plays an essential role in prostate tumorigenesis and cell growth mediated by growth regulatory factors. Here, we identified E2F1 and E2F3 mRNAs as translational targets of WDR77. We demonstrated that WDR77 regulated the...

    Mahmood Anber Altayyar, Xiumei Sheng, Zhengxin Wang

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Molecular and Cellular Biology: 40 (24)

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volume 40, issue 24

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