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Most read article(s)

  • The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
    Minireview
    The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

    The KEAP1-NRF2 pathway is the principal protective response to oxidative and electrophilic stresses. Under homeostatic conditions, KEAP1 forms part of an E3 ubiquitin ligase, which tightly regulates the activity of the transcription factor NRF2 by targeting it for ubiquitination and proteasome-dependent degradation. In response to stress, an intricate molecular mechanism facilitated by sensor cysteines within KEAP1 allows NRF2 to escape...

    Liam Baird, Masayuki Yamamoto
  • Open Access
    When Long Noncoding Becomes Protein Coding
    Minireview
    When Long Noncoding Becomes Protein Coding

    Recent advancements in genetic and proteomic technologies have revealed that more of the genome encodes proteins than originally thought possible. Specifically, some putative long noncoding RNAs (lncRNAs) have been misannotated as noncoding. Numerous lncRNAs have been found to contain short open reading frames (sORFs) which have been overlooked because of their small size. Many of these sORFs encode small proteins or micropeptides with...

    Corrine Corrina R. Hartford, Ashish Lal
  • Transcriptional and Epigenomic Regulation of Adipogenesis
    Minireview
    Transcriptional and Epigenomic Regulation of Adipogenesis

    Understanding adipogenesis, the process of adipocyte development, may provide new ways to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated actions of lineage-determining transcription factors and epigenomic regulators.

    Ji-Eun Lee, Hannah Schmidt, Binbin Lai, Kai Ge
  • Open Access
    Translational Control during Cellular Senescence
    Minireview
    Translational Control during Cellular Senescence

    Senescence is a state of long-term cell cycle arrest that arises in cells that have incurred sublethal damage. While senescent cells no longer replicate, they remain metabolically active and further develop unique and stable phenotypes that are not present in proliferating cells. On one hand, senescent cells increase in size, maintain an active mTORC1 complex, and produce and secrete a substantial amount of inflammatory proteins as part...

    Matthew J. Payea, Carlos Anerillas, Ravi Tharakan, Myriam Gorospe
  • Lysine Demethylase KDM6A in Differentiation, Development, and Cancer
    Minireview
    Lysine Demethylase KDM6A in Differentiation, Development, and Cancer

    Lysine demethylase 6A (KDM6A), also known as UTX, belongs to the KDM6 family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B (JMJD3). The KDM6A protein contains six tetratricopeptide repeat (TPR) domains and an enzymatic Jumonji C (JmjC) domain that catalyzes the removal of di- and trimethylation on H3K27. KDM6A physically associates with histone H3 lysine 4 monomethyltransferases MLL3 (KMT2C) and MLL4 (...

    Nhien Tran, Aaron Broun, Kai Ge
  • Nrf2 Suppresses Oxidative Stress and Inflammation in <em>App</em> Knock-In Alzheimer’s Disease Model Mice
    Research Article | Spotlight
    Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice

    Nrf2 (NF-E2-related-factor 2) is a stress-responsive transcription factor that protects cells against oxidative stresses. To clarify whether Nrf2 prevents Alzheimer’s disease (AD), AD model AppNL-G-F/NL-G-F knock-in (AppNLGF) mice were studied in combination with genetic Nrf2 induction model Keap1FA/FA mice. While AppNLGF mice displayed shorter latency to...

    Akira Uruno, Daisuke Matsumaru, Rie Ryoke, Ritsumi Saito, Shiori Kadoguchi, Daisuke Saigusa, Takashi Saito, Takaomi C. Saido, Ryuta Kawashima, Masayuki Yamamoto
  • Looking Down on NF-κB
    Minireview
    Looking Down on NF-κB

    The diversified NF-κB transcription factor family has been extensively characterized in organisms ranging from flies to humans. However, homologs of NF-κB and many upstream signaling components have recently been characterized in basal phyla, including Cnidaria (sea anemones, corals, hydras, and jellyfish), Porifera (sponges), and single-celled protists, including Capsaspora...

    Leah M. Williams, Thomas D. Gilmore
  • Open Access
    Omomyc Reveals New Mechanisms To Inhibit the MYC Oncogene
    Research Article
    Omomyc Reveals New Mechanisms To Inhibit the MYC Oncogene

    The MYC oncogene is upregulated in human cancers by translocation, amplification, and mutation of cellular pathways that regulate Myc. Myc/Max heterodimers bind to E box sequences in the promoter regions of genes and activate transcription.

    Mark J. Demma, Claudio Mapelli, Angie Sun, Smaranda Bodea, Benjamin Ruprecht, Sarah Javaid, Derek Wiswell, Eric Muise, Shiying Chen, John Zelina, Federica Orvieto, Alessia Santoprete, Simona Altezza, Federica Tucci, Enrique Escandon, Brian Hall, Kallol Ray, Abbas Walji, Jennifer O’Neil
  • Transcriptome-Wide Comparison of Stress Granules and P-Bodies Reveals that Translation Plays a Major Role in RNA Partitioning
    Research Article | Spotlight
    Transcriptome-Wide Comparison of Stress Granules and P-Bodies Reveals that Translation Plays a Major Role in RNA Partitioning

    The eukaryotic cytosol contains multiple RNP granules, including P-bodies and stress granules. Three different methods have been used to describe the transcriptome of stress granules or P-bodies, but how these methods compare and how RNA partitioning occurs between P-bodies and stress granules have not been addressed. Here, we compare the analysis of the stress granule transcriptome based on differential centrifugation with and without...

    Tyler Matheny, Bhalchandra S. Rao, Roy Parker
  • Open Access
    Age-Dependent Ribosomal DNA Variations in Mice
    Research Article
    Age-Dependent Ribosomal DNA Variations in Mice

    The rRNA gene, which consists of tandem repetitive arrays (ribosomal DNA [rDNA] repeat), is one of the most unstable regions in the genome. The rDNA repeat in the budding yeast Saccharomyces cerevisiae is known to become unstable as the cell ages. However, it is unclear how the rDNA repeat changes in aging mammalian cells. Using quantitative single-cell analyses, we...

    Eriko Watada, Sihan Li, Yutaro Hori, Katsunori Fujiki, Katsuhiko Shirahige, Toshifumi Inada, Takehiko Kobayashi

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