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Research Article

Genetic and physical analyses of sister chromatid exchange in yeast meiosis.

H Sun, D Dawson, J W Szostak
H Sun
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.
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D Dawson
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.
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J W Szostak
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.
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DOI: 10.1128/MCB.11.12.6328
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ABSTRACT

We have used nonessential circular minichromosomes to monitor sister chromatid exchange during yeast meiosis. Genetic analysis shows that a 64-kb circular minichromosome undergoes sister chromatid exchange during 40% of meioses. This frequency is not reduced by the presence of a homologous linear minichromosome. Furthermore, sister chromatid exchange can be stimulated by the presence of a 12-kb ARG4 DNA fragment, which contains initiation sites for meiotic gene conversion. Using physical analysis, we have directly identified a product of sister chromatid exchange: a head-to-tail dimer form of a circular minichromosome. This dimer form is absent in a rad50S mutant strain, which is deficient in processing of the ends of meiosis-specific double-stranded breaks into single-stranded DNA tails. Our studies suggest that meiotic sister chromatid exchange is stimulated by the same mechanism as meiotic homolog exchange.

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Genetic and physical analyses of sister chromatid exchange in yeast meiosis.
H Sun, D Dawson, J W Szostak
Molecular and Cellular Biology Dec 1991, 11 (12) 6328-6336; DOI: 10.1128/MCB.11.12.6328

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Genetic and physical analyses of sister chromatid exchange in yeast meiosis.
H Sun, D Dawson, J W Szostak
Molecular and Cellular Biology Dec 1991, 11 (12) 6328-6336; DOI: 10.1128/MCB.11.12.6328
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