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Research Article

Cross-resistance to UV radiation of a cisplatin-resistant human cell line: overexpression of cellular factors that recognize UV-modified DNA.

C C Chao, S L Huang, H M Huang, S Lin-Chao
C C Chao
Department of Biochemistry and Medicine, Chang Gung Medical College, Taoyuan, Taiwan, Republic of China.
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S L Huang
Department of Biochemistry and Medicine, Chang Gung Medical College, Taoyuan, Taiwan, Republic of China.
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H M Huang
Department of Biochemistry and Medicine, Chang Gung Medical College, Taoyuan, Taiwan, Republic of China.
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S Lin-Chao
Department of Biochemistry and Medicine, Chang Gung Medical College, Taoyuan, Taiwan, Republic of China.
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DOI: 10.1128/MCB.11.4.2075
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ABSTRACT

A human cell line selected for cisplatin resistance (CPR) was irradiated with UV light and showed cross-resistance to UV light. Applying a modified chloramphenicol acetyltransferase assay, we observed that CPR cells acquired enhanced host cell reactivation of a transfected plasmid carrying UV damage. Gel mobility shift analysis indicated that two nuclear factors that recognize UV-modified DNA were overexpressed in CPR cells. In addition, factors that bind UV-modified DNA were independent from the factors that bind cisplatin-modified DNA. The significance of the identified binding factors, possibly DNA repair enzymes, is discussed.

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Cross-resistance to UV radiation of a cisplatin-resistant human cell line: overexpression of cellular factors that recognize UV-modified DNA.
C C Chao, S L Huang, H M Huang, S Lin-Chao
Molecular and Cellular Biology Apr 1991, 11 (4) 2075-2080; DOI: 10.1128/MCB.11.4.2075

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Cross-resistance to UV radiation of a cisplatin-resistant human cell line: overexpression of cellular factors that recognize UV-modified DNA.
C C Chao, S L Huang, H M Huang, S Lin-Chao
Molecular and Cellular Biology Apr 1991, 11 (4) 2075-2080; DOI: 10.1128/MCB.11.4.2075
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