Table of Contents

Research Article

• Research Article

  Are yeast chitin synthases regulated at the transcriptional or the posttranslational level?

  W J Choi, B Santos, A Durán, E Cabib
• Research Article

  Transcriptional regulation of NF-kappa B2: evidence for kappa B-mediated positive and negative autoregulation.

  S Liptay, R M Schmid, E G Nabel, G J Nabel
• Research Article

  The basic helix-loop-helix-zipper domain of TFE3 mediates enhancer-promoter interaction.

  S E Artandi, C Cooper, A Shrivastava, K Calame
• Research Article

  In organello footprint analysis of human mitochondrial DNA: human mitochondrial transcription factor A interactions at the origin of replication.

  S C Ghivizzani, C S Madsen, M R Nelen, C V Ammini, W W Hauswirth
• Research Article

  Involvement of JunD in transcriptional activation of the orphan receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells.

  J K Yoon, L F Lau
• Research Article

  AP-1, ETS, and transcriptional silencers regulate retinoic acid-dependent induction of keratin 18 in embryonic cells.

  R Pankov, N Neznanov, A Umezawa, R G Oshima
• Research Article

  Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer.

  L Dailey, H Yuan, C Basilico
• Research Article

  Identification and characterization of a novel GGA/C-binding protein, GBP-i, that is rapidly inducible by cytokines.

  G V Raj, K Khalili
• Research Article

  Hairpin structures are the primary amplification products: a novel mechanism for generation of inverted repeats during gene amplification.

  S Cohen, D Hassin, S Karby, S Lavi
• Research Article

  Identification and analysis of a Saccharomyces cerevisiae copper homeostasis gene encoding a homeodomain protein.

  S A Knight, K T Tamai, D J Kosman, D J Thiele
• Research Article

  Transactivation of the human p53 tumor suppressor gene by c-Myc/Max contributes to elevated mutant p53 expression in some tumors.

  B Roy, J Beamon, E Balint, D Reisman
• Research Article

  Analysis of the DNA-binding and dimerization activities of Neurospora crassa transcription factor NUC-1.

  Y Peleg, R L Metzenberg
• Research Article

  Oligonucleotides complementary to the Oxytricha nova telomerase RNA delineate the template domain and uncover a novel mode of primer utilization.

  M Melek, B T Davis, D E Shippen
• Research Article

  The Srp54 GTPase is essential for protein export in the fission yeast Schizosaccharomyces pombe.

  S M Althoff, S W Stevens, J A Wise
• Research Article

  Inhibition of platelet-derived growth factor- and epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER, an estradiol-regulated form of Raf-1.

  M L Samuels, M McMahon
• Research Article

  Further analysis of cytoplasmic polyadenylation in Xenopus embryos and identification of embryonic cytoplasmic polyadenylation element-binding proteins.

  R Simon, J D Richter
• Research Article

  Stress resistance in Saccharomyces cerevisiae is strongly correlated with assembly of a novel type of multiubiquitin chain.

  T Arnason, M J Ellison
• Research Article

  Replication factor A is required in vivo for DNA replication, repair, and recombination.

  M P Longhese, P Plevani, G Lucchini
• Research Article

  Regulated immunoglobulin (Ig) RNA processing does not require specific cis-acting sequences: non-Ig RNA can be alternatively processed in B cells and plasma cells.

  M L Peterson
• Research Article

  Functional and conserved domains of the Drosophila transcription factor encoded by the segmentation gene knirps.

  N Gerwin, A La Rosée, F Sauer, H P Halbritter, M Neumann, H Jäckle, U Nauber
• Research Article

  Analysis of RIM11, a yeast protein kinase that phosphorylates the meiotic activator IME1.

  K S Bowdish, H E Yuan, A P Mitchell
• Research Article

  Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA.

  C R Vazquez de Aldana, R C Wek, P S Segundo, A G Truesdell, A G Hinnebusch
• Research Article

  Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells.

  R G Bryan, Y Li, J H Lai, M Van, N R Rice, R R Rich, T H Tan
• Research Article

  Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activating protein SH3 domain.

  R R Mattingly, A Sorisky, M R Brann, I G Macara
• Research Article

  G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover.

  S R Salama, K B Hendricks, J Thorner
• Research Article

  NF-kappa B sites function as positive regulators of expression of the translocated c-myc allele in Burkitt's lymphoma.

  L Ji, M Arcinas, L M Boxer
• Research Article

  CpG island promoter region methylation patterns of the inactive-X-chromosome hypoxanthine phosphoribosyltransferase (Hprt) gene.

  J G Park, V M Chapman
• Research Article

  AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A).

  C A Lagnado, C Y Brown, G J Goodall
• Research Article

  Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator.

  N J Bentley, T Eisen, C R Goding
• Research Article

  A functional glucocorticoid-responsive unit composed of two overlapping inactive receptor-binding sites: evidence for formation of a receptor tetramer.

  M Garlatti, M Daheshia, E Slater, J Bouguet, J Hanoune, M Beato, R Barouki
• Research Article

  Interferons block protein kinase C-dependent but not-independent activation of Raf-1 and mitogen-activated protein kinases and mitogenesis in NIH 3T3 cells.

  J Xu, S Rockow, S Kim, W Xiong, W Li
• Research Article

  A family of complex tandem DNA repeats in the telomeres of Chironomus pallidivittatus.

  Y J Zhang, I Kamnert, C C López, M Cohn, J E Edström
• Research Article

  Mutations in the Saccharomyces cerevisiae CDC1 gene affect double-strand-break-induced intrachromosomal recombination.

  J Halbrook, M F Hoekstra
• Research Article

  AML1 is expressed in skeletal muscle and is regulated by innervation.

  X Zhu, J E Yeadon, S J Burden
• Research Article

  Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene.

  K Yasumoto, K Yokoyama, K Shibata, Y Tomita, S Shibahara
• Research Article

  A novel role for DNA photolyase: binding to DNA damaged by drugs is associated with enhanced cytotoxicity in Saccharomyces cerevisiae.

  M E Fox, B J Feldman, G Chu
• Research Article

  CD45 tyrosine phosphatase activity and membrane anchoring are required for T-cell antigen receptor signaling.

  B B Niklinska, D Hou, C June, A M Weissman, J D Ashwell
• Research Article

  Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1).

  D E Zhang, K Fujioka, C J Hetherington, L H Shapiro, H M Chen, A T Look, D G Tenen
• Research Article

  Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease.

  P Rouet, F Smih, M Jasin
• Research Article

  Special peptidyl-tRNA molecules can promote translational frameshifting without slippage.

  A Vimaladithan, P J Farabaugh
• Research Article

  Amino acid residues in the CDC25 guanine nucleotide exchange factor critical for interaction with Ras.

  W Park, R D Mosteller, D Broek
• Research Article

  Erythroid cell-specific determinants of alpha-globin mRNA stability.

  I M Weiss, S A Liebhaber
• Research Article

  Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.

  O Colamonici, H Yan, P Domanski, R Handa, D Smalley, J Mullersman, M Witte, K Krishnan, J Krolewski
• Research Article

  Multiple positive and negative regulatory elements in the promoter of the mouse homeobox gene Hoxb-4.

  A Gutman, J Gilthorpe, P W Rigby
• Research Article

  Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways.

  K T Tamai, X Liu, P Silar, T Sosinowski, D J Thiele
• Research Article

  Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

  B Shan, W H Lee
• Research Article

  RNA editing and mitochondrial genomic organization in the cryptobiid kinetoplastid protozoan Trypanoplasma borreli.

  D A Maslov, L Simpson
• Research Article

  Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit.

  A Jenny, H P Hauri, W Keller
• Research Article

  Ligand-dependent occupancy of the retinoic acid receptor beta 2 promoter in vivo.

  A Dey, S Minucci, K Ozato
• Research Article

  Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3.

  A X Zhu, Y Zhao, D E Moller, J S Flier
• Research Article

  RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.

  T Jelinek, A D Catling, C W Reuter, S A Moodie, A Wolfman, M J Weber
• Research Article

  Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

  P Belgrader, J Cheng, X Zhou, L S Stephenson, L E Maquat
• Research Article

  Transposition of the yeast retroviruslike element Ty3 is dependent on the cell cycle.

  T M Menees, S B Sandmeyer
• Research Article

  Positive and negative regulation of cell proliferation by E2F-1: influence of protein level and human papillomavirus oncoproteins.

  R M Melillo, K Helin, D R Lowy, J T Schiller
• Research Article

  Targeted expression of the E6 and E7 oncogenes of human papillomavirus type 16 in the epidermis of transgenic mice elicits generalized epidermal hyperplasia involving autocrine factors.

  P Auewarakul, L Gissmann, A Cid-Arregui
• Research Article

  MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein, is required for Ca2+ influx and mating.

  H Iida, H Nakamura, T Ono, M S Okumura, Y Anraku
• Research Article

  Type I adenylyl cyclase functions as a coincidence detector for control of cyclic AMP response element-mediated transcription: synergistic regulation of transcription by Ca2+ and isoproterenol.

  S Impey, G Wayman, Z Wu, D R Storm
• Research Article

  The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase.

  B T Roberts, K A Farr, M A Hoyt
• Research Article

  The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins.

  A Molnár, K Georgopoulos
• Research Article

  Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.

  K Monica, D P LeBrun, D A Dedera, R Brown, M L Cleary
• Research Article

  Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2.

  S K Thukral, G C Blain, K K Chang, S Fields
• Research Article

  H1TF2A, the large subunit of a heterodimeric, glutamine-rich CCAAT-binding transcription factor involved in histone H1 cell cycle regulation.

  R Martinelli, N Heintz
• Research Article

  Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes.

  A B Reynolds, J Daniel, P D McCrea, M J Wheelock, J Wu, Z Zhang
• Research Article

  Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation.

  M L Whitelaw, J A Gustafsson, L Poellinger
• Research Article

  The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.

  D X Wen, Y F Xu, D E Mais, M E Goldman, D P McDonnell
• Research Article

  Identification of functional targets of the Zta transcriptional activator by formation of stable preinitiation complex intermediates.

  P Lieberman
• Research Article

  Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

  H K Sluss, T Barrett, B Dérijard, R J Davis
• Research Article

  Efficiency of insertion versus replacement vector targeting varies at different chromosomal loci.

  P Hasty, M Crist, M Grompe, A Bradley
• Research Article

  The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.

  S Gangloff, J P McDonald, C Bendixen, L Arthur, R Rothstein
• Research Article

  A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm.

  J Flach, M Bossie, J Vogel, A Corbett, T Jinks, D A Willins, P A Silver
• Research Article

  Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern.

  K R Loeb, A L Haas
• Research Article

  Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.

  M Xu, K A Sheppard, C Y Peng, A S Yee, H Piwnica-Worms
• Research Article

  Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding.

  B Tang, H Mano, T Yi, J N Ihle
• Research Article

  A factor that regulates the class II major histocompatibility complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein.

  M Sugawara, T Scholl, P D Ponath, J L Strominger
• Research Article

  Cellular aggregation enhances MyoD-directed skeletal myogenesis in embryonal carcinoma cells.

  I S Skerjanc, R S Slack, M W McBurney
• Research Article

  Alternate RNA splicing of murine nfkb1 generates a nuclear isoform of the p50 precursor NF-kappa B1 that can function as a transactivator of NF-kappa B-regulated transcription.

  R J Grumont, J Fecondo, S Gerondakis
• Research Article

  Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements.

  C Y Chen, A B Shyu
• Research Article

  Mouse p53 represses the rat brain creatine kinase gene but activates the rat muscle creatine kinase gene.

  J Zhao, F I Schmieg, D T Simmons, G R Molloy