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Research Article

Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signalling.

A Kawahara, Y Minami, T Taniguchi
A Kawahara
Institute for Molecular and Cellular Biology, Osaka University, Japan.
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Y Minami
Institute for Molecular and Cellular Biology, Osaka University, Japan.
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T Taniguchi
Institute for Molecular and Cellular Biology, Osaka University, Japan.
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DOI: 10.1128/MCB.14.8.5433
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ABSTRACT

The high-affinity interleukin 2 receptor (IL-2R) consists of at least three distinct subunits: the IL-2R alpha chain (IL-2R alpha), beta chain (IL-2R beta), and gamma chain (IL-2R gamma). It has been shown that the cytoplasmic region of IL-2R beta, but not of IL-2R alpha, is essential for IL-2 signalling to the cell interior. In the present study, we examined the functional role of the IL-2R gamma cytoplasmic region in the IL-3-dependent mouse hematopoietic cell line BAF-B03, which expresses the endogenous IL-2R alpha and IL-2R gamma, or its subline F7, which additionally expresses human IL-2R beta cDNA. We show that overexpression of a mutant IL-2R gamma, lacking all but 7 amino acids of its cytoplasmic region, results in the selective inhibition of IL-2-induced c-fos gene activation and cellular proliferation in F7 cells. When two chimeric receptor molecules in which the cytoplasmic regions of IL-2R beta and IL-2R gamma had been swapped with each other (IL-2R beta/gamma and IL-2R gamma/beta) were coexpressed in BAF-B03, the cells responded to IL-2. These results indicate the critical importance of the IL-2-induced functional cooperation of the two cytoplasmic regions. Finally, we provide evidence that the IL-2R gamma cytoplasmic region is also critical for the IL-4 and IL-7-induced growth signal transduction in BAF-B03.

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Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signalling.
A Kawahara, Y Minami, T Taniguchi
Molecular and Cellular Biology Aug 1994, 14 (8) 5433-5440; DOI: 10.1128/MCB.14.8.5433

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Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signalling.
A Kawahara, Y Minami, T Taniguchi
Molecular and Cellular Biology Aug 1994, 14 (8) 5433-5440; DOI: 10.1128/MCB.14.8.5433
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