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Journal Article | Research Support, Non-U.S. Gov't

Two-step activation of meiosis by the mat1 locus in Schizosaccharomyces pombe.

M Willer, L Hoffmann, U Styrkársdóttir, R Egel, J Davey, O Nielsen
M Willer
Department of Genetics, University of Copenhagen, Denmark.
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L Hoffmann
Department of Genetics, University of Copenhagen, Denmark.
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U Styrkársdóttir
Department of Genetics, University of Copenhagen, Denmark.
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R Egel
Department of Genetics, University of Copenhagen, Denmark.
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J Davey
Department of Genetics, University of Copenhagen, Denmark.
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O Nielsen
Department of Genetics, University of Copenhagen, Denmark.
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DOI: 10.1128/MCB.15.9.4964
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ABSTRACT

The mat1 locus is a key regulator of both conjugation and meiosis in the fission yeast Schizosaccharomyces pombe. Two alternative DNA segments of this locus, mat1-P and mat1-M, specify the haploid cell types (Plus and Minus). Each segment includes two genes: mat1-P includes mat1-Pc and mat1-Pm, while mat1-M includes mat1-Mc and mat1-Mm. The mat1-Pc and mat1-Mc genes are responsible for establishing the pheromone communication system that mediates conjugation between P and M cells, while all four mat1 genes are required for meiosis in diploid P/M cells. Our understanding of the initiation of meiosis is based largely on indirect observations, and a more precise investigation of these events was required to define the interaction between the mat1 genes. Here we resolve this issue using synthetic pheromones and P/M strains with mutations in either mat1-Pc or mat1-Mc. Our results suggest a model in which the mat1 locus plays two roles in controlling meiosis. In the first instance, the mat1-Pc and mat1-Mc functions are required to produce the mating pheromones and receptors that allow the generation of a pheromone signal. This signal is required to induce the expression of mat1-Pm and mat1-Mm. This appears to be the major pheromone-dependent step in controlling meiosis since ectopic expression of these genes allows meiosis in the absence of mat1-Pc and mat1-Mc. The mat1-Pm and mat1-Mm products complete the initiation of meiosis by activating transcription of the mei3 gene.

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Two-step activation of meiosis by the mat1 locus in Schizosaccharomyces pombe.
M Willer, L Hoffmann, U Styrkársdóttir, R Egel, J Davey, O Nielsen
Molecular and Cellular Biology Sep 1995, 15 (9) 4964-4970; DOI: 10.1128/MCB.15.9.4964

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Two-step activation of meiosis by the mat1 locus in Schizosaccharomyces pombe.
M Willer, L Hoffmann, U Styrkársdóttir, R Egel, J Davey, O Nielsen
Molecular and Cellular Biology Sep 1995, 15 (9) 4964-4970; DOI: 10.1128/MCB.15.9.4964
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