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Comparative Study | Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S.

TFG/TAF30/ANC1, a component of the yeast SWI/SNF complex that is similar to the leukemogenic proteins ENL and AF-9.

B R Cairns, N L Henry, R D Kornberg
B R Cairns
Department of Structural Biology, Stanford University School of Medicine, California 94305, USA.
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N L Henry
Department of Structural Biology, Stanford University School of Medicine, California 94305, USA.
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R D Kornberg
Department of Structural Biology, Stanford University School of Medicine, California 94305, USA.
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DOI: 10.1128/MCB.16.7.3308
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ABSTRACT

The SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products are all required for proper transcriptional control of many genes in the yeast Saccharomyces cerevisiae. Genetic studies indicated that these gene products might form a multiprotein SWI/SNF complex important for chromatin transitions preceding transcription from RNA polymerase II promoters. Biochemical studies identified a SWI/SNF complex containing these and at least six additional polypeptides. Here we show that the 29-kDa component of the SWI/SNF complex is identical to TFG3/TAF30/ANC1. Thus, a component of the SWI/SNF complex is also a member of the TFIIF and TFIID transcription complexes. TFG3 interacted with the SNF5 component of the SWI/SNF complex in protein interaction blots. TFG3 is significantly similar to ENL and AF-9, two proteins implicated in human acute leukemia. These results suggest that ENL and AF-9 proteins interact with the SNF5 component of the human SWI/SNF complex and raise the possibility that the SWI/SNF complex is involved in acute leukemia.

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TFG/TAF30/ANC1, a component of the yeast SWI/SNF complex that is similar to the leukemogenic proteins ENL and AF-9.
B R Cairns, N L Henry, R D Kornberg
Molecular and Cellular Biology Jul 1996, 16 (7) 3308-3316; DOI: 10.1128/MCB.16.7.3308

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TFG/TAF30/ANC1, a component of the yeast SWI/SNF complex that is similar to the leukemogenic proteins ENL and AF-9.
B R Cairns, N L Henry, R D Kornberg
Molecular and Cellular Biology Jul 1996, 16 (7) 3308-3316; DOI: 10.1128/MCB.16.7.3308
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