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Journal Article | Research Support, U.S. Gov't, P.H.S.

Lck regulates Vav activation of members of the Rho family of GTPases.

J Han, B Das, W Wei, L Van Aelst, R D Mosteller, R Khosravi-Far, J K Westwick, C J Der, D Broek
J Han
Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, School of Medicine, University of Southern California, Los Angeles 90033, USA.
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B Das
Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, School of Medicine, University of Southern California, Los Angeles 90033, USA.
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W Wei
Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, School of Medicine, University of Southern California, Los Angeles 90033, USA.
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L Van Aelst
Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, School of Medicine, University of Southern California, Los Angeles 90033, USA.
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R D Mosteller
Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, School of Medicine, University of Southern California, Los Angeles 90033, USA.
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R Khosravi-Far
Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, School of Medicine, University of Southern California, Los Angeles 90033, USA.
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J K Westwick
Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, School of Medicine, University of Southern California, Los Angeles 90033, USA.
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C J Der
Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, School of Medicine, University of Southern California, Los Angeles 90033, USA.
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D Broek
Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, School of Medicine, University of Southern California, Los Angeles 90033, USA.
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DOI: 10.1128/MCB.17.3.1346
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ABSTRACT

Vav is a member of a family of oncogene proteins that share an approximately 250-amino-acid motif called a Dbl homology domain. Paradoxically, Dbl itself and other proteins containing a Dbl domain catalyze GTP-GDP exchange for Rho family proteins, whereas Vav has been reported to catalyze GTP-GDP exchange for Ras proteins. We present Saccharomyces cerevisiae genetic data, in vitro biochemical data, and animal cell biological data indicating that Vav is a guanine nucleotide exchange factor for Rho-related proteins, but in similar genetic and biochemical experiments we fail to find evidence that Vav is a guanine nucleotide exchange factor for Ras. Further, we present data indicating that the Lck kinase activates the guanine nucleotide exchange factor and transforming activity of Vav.

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Lck regulates Vav activation of members of the Rho family of GTPases.
J Han, B Das, W Wei, L Van Aelst, R D Mosteller, R Khosravi-Far, J K Westwick, C J Der, D Broek
Molecular and Cellular Biology Mar 1997, 17 (3) 1346-1353; DOI: 10.1128/MCB.17.3.1346

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Lck regulates Vav activation of members of the Rho family of GTPases.
J Han, B Das, W Wei, L Van Aelst, R D Mosteller, R Khosravi-Far, J K Westwick, C J Der, D Broek
Molecular and Cellular Biology Mar 1997, 17 (3) 1346-1353; DOI: 10.1128/MCB.17.3.1346
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