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GENE EXPRESSION

Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and Ubiquitination

Seiichi Nakamura, Jack A. Roth, Tapas Mukhopadhyay
Seiichi Nakamura
Section of Thoracic Molecular Oncology, Departments of Thoracic and Cardiovascular Surgery and
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Jack A. Roth
Section of Thoracic Molecular Oncology, Departments of Thoracic and Cardiovascular Surgery and
Tumor Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
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Tapas Mukhopadhyay
Section of Thoracic Molecular Oncology, Departments of Thoracic and Cardiovascular Surgery and
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DOI: 10.1128/MCB.20.24.9391-9398.2000
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Article Information

DOI 
https://doi.org/10.1128/MCB.20.24.9391-9398.2000
PubMed 
11094089

Published By 
American Society for Microbiology Journals
History 
  • Received February 18, 2000
  • Returned for modification April 4, 2000
  • Accepted September 11, 2000
  • Published online December 15, 2000.

Copyright & Usage 
Copyright © 2000 American Society for Microbiology

Author Information

  1. Seiichi Nakamura1,
  2. Jack A. Roth1,2 and
  3. Tapas Mukhopadhyay1*
  1. Section of Thoracic Molecular Oncology, Departments of Thoracic and Cardiovascular Surgery1 and
  2. Tumor Biology,2 The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
  • ↵* Corresponding author. Mailing address: Department of Thoracic and Cardiovascular Surgery, Box 109, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030. Phone: (713) 745-4542. Fax: (713) 794-4901. E-mail:tmukhopa{at}notes.mdacc.tmc.edu.

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Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and Ubiquitination
Seiichi Nakamura, Jack A. Roth, Tapas Mukhopadhyay
Molecular and Cellular Biology Dec 2000, 20 (24) 9391-9398; DOI: 10.1128/MCB.20.24.9391-9398.2000

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Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and Ubiquitination
Seiichi Nakamura, Jack A. Roth, Tapas Mukhopadhyay
Molecular and Cellular Biology Dec 2000, 20 (24) 9391-9398; DOI: 10.1128/MCB.20.24.9391-9398.2000
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KEYWORDS

GTPase-Activating Proteins
Genes, p53
Nuclear Proteins
Protein Structure, Tertiary
Proto-Oncogene Proteins
Tumor Suppressor Protein p53

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