Strand Bias in Targeted Gene Repair Is Influenced by Transcriptional Activity

Li Liu; Michael C. Rice; Miya Drury; Shuqiu Cheng; Howard Gamper; Eric B. Kmiec

doi:10.1128/MCB.22.11.3852-3863.2002

DOI: 10.1128/MCB.22.11.3852-3863.2002

Article Information

DOI

https://doi.org/10.1128/MCB.22.11.3852-3863.2002

PubMed

11997519

Published By

American Society for Microbiology Journals

History

Received December 27, 2001
Returned for modification February 11, 2002
Accepted February 15, 2002
Published online June 1, 2002.

Author Information

Li Liu¹,
Michael C. Rice¹,
Miya Drury¹,
Shuqiu Cheng²,
Howard Gamper¹ and
Eric B. Kmiec¹ *

¹Department of Biology and Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19716
²Genomics Division, NaPro BioTherapeutics, Inc., Delaware Biotechnology Institute, Newark, Delaware 19711

↵* Corresponding author. Mailing address: Department of Biology and Delaware Biotechnology Institute, University of Delaware, Newark, DE 19716. Phone: (302) 831-3420. Fax: (302) 831-3427. E-mail: ekmiec{at}udel.edu .

View Abstract

Article usage

Article usage: April 2002 to January 2021

Rendering graph...

	Abstract	Full	Pdf
Apr 2002	0	0	1
May 2002	165	152	110
Jun 2002	19	50	35
Jul 2002	11	40	11
Aug 2002	8	50	24
Sep 2002	15	48	15
Oct 2002	8	40	30
Nov 2002	10	29	17
Dec 2002	7	38	42
Jan 2003	2	24	40
Feb 2003	1	30	30
Mar 2003	2	15	20
Apr 2003	2	5	11
May 2003	3	16	15
Jun 2003	1	16	20
Jul 2003	14	21	19
Aug 2003	12	24	4
Sep 2003	11	31	39
Oct 2003	19	40	32
Nov 2003	16	36	16
Dec 2003	13	26	52
Jan 2004	17	36	12
Feb 2004	11	29	20
Mar 2004	16	40	17
Apr 2004	16	20	10
May 2004	20	38	11
Jun 2004	20	45	7
Jul 2004	27	40	18
Aug 2004	20	47	8
Sep 2004	14	31	10
Oct 2004	17	44	9
Nov 2004	15	21	9
Dec 2004	12	21	11
Jan 2005	6	11	5
Feb 2005	5	13	9
Mar 2005	1	21	15
Apr 2005	5	32	6
May 2005	7	16	2
Jun 2005	9	22	4
Jul 2005	3	12	13
Aug 2005	9	18	16
Sep 2005	3	19	7
Oct 2005	8	21	7
Nov 2005	8	18	5
Dec 2005	4	12	0
Jan 2006	12	23	6
Feb 2006	12	18	1
Mar 2006	5	19	3
Apr 2006	0	8	7
May 2006	3	4	2
Jun 2006	9	22	2
Jul 2006	7	40	5
Aug 2006	3	20	3
Sep 2006	10	9	7
Oct 2006	18	14	8
Nov 2006	11	12	2
Dec 2006	5	7	6
Jan 2007	10	7	4
Feb 2007	2	3	7
Mar 2007	9	7	5
Apr 2007	11	12	7
May 2007	7	10	6
Jun 2007	8	8	8
Jul 2007	4	5	6
Aug 2007	4	6	4
Sep 2007	7	5	1
Oct 2007	5	5	3
Nov 2007	8	7	6
Dec 2007	3	8	4
Jan 2008	1	4	1
Feb 2008	8	2	2
Mar 2008	3	2	0
Apr 2008	9	10	2
May 2008	15	11	7
Jun 2008	10	7	3
Jul 2008	13	9	4
Aug 2008	4	6	1
Sep 2008	14	7	1
Oct 2008	10	8	2
Nov 2008	7	7	2
Dec 2008	3	5	2
Jan 2009	5	3	4
Feb 2009	14	8	6
Mar 2009	9	8	5
Apr 2009	7	3	2
May 2009	7	6	3
Jun 2009	6	3	2
Jul 2009	5	7	0
Aug 2009	3	2	0
Sep 2009	6	2	3
Oct 2009	5	5	1
Nov 2009	4	6	1
Dec 2009	7	3	5
Jan 2010	3	3	2
Feb 2010	0	5	4
Mar 2010	4	6	5
Apr 2010	3	6	3
May 2010	3	5	5
Jun 2010	2	5	1
Jul 2010	5	4	4
Aug 2010	6	2	5
Sep 2010	4	6	1
Oct 2010	7	2	4
Nov 2010	13	9	6
Dec 2010	7	5	2
Jan 2011	8	6	8
Feb 2011	9	9	11
Mar 2011	10	7	10
Apr 2011	6	12	1
May 2011	9	15	12
Jun 2011	8	4	5
Jul 2011	6	8	2
Aug 2011	7	5	5
Sep 2011	8	3	3
Oct 2011	3	8	1
Nov 2011	5	5	8
Dec 2011	12	7	5
Jan 2012	10	10	2
Feb 2012	5	4	8
Mar 2012	13	11	7
Apr 2012	15	10	7
May 2012	10	9	3
Jun 2012	10	13	5
Jul 2012	13	4	5
Aug 2012	11	9	7
Sep 2012	7	1	0
Oct 2012	6	8	7
Nov 2012	15	14	8
Dec 2012	6	7	4
Jan 2013	11	14	4
Feb 2013	10	3	2
Mar 2013	14	3	2
Apr 2013	21	7	8
May 2013	12	5	6
Jun 2013	15	3	7
Jul 2013	8	2	0
Aug 2013	3	6	1
Sep 2013	14	8	1
Oct 2013	2	8	2
Nov 2013	5	4	0
Dec 2013	8	0	2
Jan 2014	9	1	1
Feb 2014	3	1	3
Mar 2014	11	5	5
Apr 2014	16	4	4
May 2014	11	4	0
Jun 2014	16	7	11
Jul 2014	18	15	0
Aug 2014	25	4	1
Sep 2014	17	11	2
Oct 2014	4	7	2
Nov 2014	20	2	2
Dec 2014	17	5	4
Jan 2015	39	5	1
Feb 2015	23	9	0
Mar 2015	7	3	3
Apr 2015	5	3	0
May 2015	8	5	2
Jun 2015	11	4	2
Jul 2015	11	5	2
Aug 2015	15	10	0
Sep 2015	5	4	4
Oct 2015	8	2	3
Nov 2015	3	2	1
Dec 2015	6	2	1
Jan 2016	2	4	1
Feb 2016	6	2	1
Mar 2016	7	3	8
Apr 2016	6	5	1
May 2016	9	6	3
Jun 2016	8	2	1
Jul 2016	11	4	2
Aug 2016	11	2	0
Sep 2016	6	5	0
Oct 2016	9	6	0
Nov 2016	10	12	0
Dec 2016	10	6	1
Jan 2017	13	7	2
Feb 2017	9	7	0
Mar 2017	12	7	1
Apr 2017	14	4	2
May 2017	9	9	1
Jun 2017	8	4	0
Jul 2017	6	2	3
Aug 2017	5	4	1
Sep 2017	7	5	1
Oct 2017	9	5	0
Nov 2017	12	9	1
Dec 2017	3	1	0
Jan 2018	3	0	0
Feb 2018	5	1	0
Mar 2018	6	4	9
Apr 2018	8	12	3
May 2018	9	9	1
Jun 2018	6	5	1
Jul 2018	2	4	1
Aug 2018	4	9	1
Sep 2018	1	12	1
Oct 2018	3	21	5
Nov 2018	0	5	1
Dec 2018	1	13	2
Jan 2019	0	5	1
Feb 2019	0	1	1
Mar 2019	2	2	4
Apr 2019	2	9	4
May 2019	0	10	7
Jun 2019	2	4	3
Jul 2019	1	3	4
Aug 2019	1	2	3
Sep 2019	2	2	4
Oct 2019	3	1	2
Nov 2019	6	6	7
Dec 2019	0	4	5
Jan 2020	0	4	1
Feb 2020	0	2	1
Mar 2020	3	49	4
Apr 2020	0	39	1
May 2020	3	8	5
Jun 2020	0	2	1
Jul 2020	1	6	3
Aug 2020	2	2	1
Sep 2020	6	6	3
Oct 2020	1	30	2
Nov 2020	5	5	5
Dec 2020	3	5	2
Jan 2021	1	0	5