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CELL GROWTH AND DEVELOPMENT

Targeted Disruption of NFATc3, but Not NFATc4, Reveals an Intrinsic Defect in Calcineurin-Mediated Cardiac Hypertrophic Growth

Benjamin J. Wilkins, Leon J. De Windt, Orlando F. Bueno, Julian C. Braz, Betty J. Glascock, Thomas F. Kimball, Jeffery D. Molkentin
Benjamin J. Wilkins
1Division of Molecular Cardiovascular Biology
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Leon J. De Windt
1Division of Molecular Cardiovascular Biology
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Orlando F. Bueno
1Division of Molecular Cardiovascular Biology
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Julian C. Braz
1Division of Molecular Cardiovascular Biology
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Betty J. Glascock
2Cardiology Division, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati Ohio 45229-3039
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Thomas F. Kimball
2Cardiology Division, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati Ohio 45229-3039
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Jeffery D. Molkentin
1Division of Molecular Cardiovascular Biology
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  • For correspondence: molkj0@chmcc.org
DOI: 10.1128/MCB.22.21.7603-7613.2002
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ABSTRACT

A calcineurin-nuclear factor of activated T cells (NFAT) regulatory pathway has been implicated in the control of cardiac hypertrophy, suggesting one mechanism whereby alterations in intracellular calcium handling are linked to the expression of hypertrophy-associated genes. Although recent studies have demonstrated a necessary role for calcineurin as a mediator of cardiac hypertrophy, the potential involvement of NFAT transcription factors as downstream effectors of calcineurin signaling has not been evaluated. Accordingly, mice with targeted disruptions in NFATc3 and NFATc4 genes were characterized. Whereas the loss of NFATc4 did not compromise the ability of the myocardium to undergo hypertrophic growth, NFATc3-null mice demonstrated a significant reduction in calcineurin transgene-induced cardiac hypertrophy at 19 days, 26 days, 6 weeks, 8 weeks, and 10 weeks of age. NFATc3-null mice also demonstrated attenuated pressure overload- and angiotensin II-induced cardiac hypertrophy. These results provide genetic evidence that calcineurin-regulated responses require NFAT effectors in vivo.

  • Copyright © 2002 American Society for Microbiology
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Targeted Disruption of NFATc3, but Not NFATc4, Reveals an Intrinsic Defect in Calcineurin-Mediated Cardiac Hypertrophic Growth
Benjamin J. Wilkins, Leon J. De Windt, Orlando F. Bueno, Julian C. Braz, Betty J. Glascock, Thomas F. Kimball, Jeffery D. Molkentin
Molecular and Cellular Biology Nov 2002, 22 (21) 7603-7613; DOI: 10.1128/MCB.22.21.7603-7613.2002

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Targeted Disruption of NFATc3, but Not NFATc4, Reveals an Intrinsic Defect in Calcineurin-Mediated Cardiac Hypertrophic Growth
Benjamin J. Wilkins, Leon J. De Windt, Orlando F. Bueno, Julian C. Braz, Betty J. Glascock, Thomas F. Kimball, Jeffery D. Molkentin
Molecular and Cellular Biology Nov 2002, 22 (21) 7603-7613; DOI: 10.1128/MCB.22.21.7603-7613.2002
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KEYWORDS

calcineurin
DNA-Binding Proteins
mutagenesis
transcription factors

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