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CELL GROWTH AND DEVELOPMENT

Ash1 Protein, an Asymmetrically Localized Transcriptional Regulator, Controls Filamentous Growth and Virulence of Candida albicans

Diane O. Inglis, Alexander D. Johnson
Diane O. Inglis
Department of Biochemistry and Biophysics and Department of Microbiology and Immunology, University of California—San Francisco, San Francisco, California 94143
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Alexander D. Johnson
Department of Biochemistry and Biophysics and Department of Microbiology and Immunology, University of California—San Francisco, San Francisco, California 94143
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  • For correspondence: ajohnson@cgl.ucsf.edu
DOI: 10.1128/MCB.22.24.8669-8680.2002
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ABSTRACT

In response to a number of distinct environmental conditions, the fungal pathogen Candida albicans undergoes a morphological transition from a round, yeast form to a series of elongated, filamentous forms. This transition is believed to be critical for virulence in a mouse model of disseminated candidiasis. Here we describe the characterization of C. albicans ASH1, a gene that encodes an asymmetrically localized transcriptional regulatory protein involved in this response. We show that C. albicans ash1 mutants are defective in responding to some filament-inducing conditions. We also show that Ash1p is preferentially localized to daughter cell nuclei in the budding-yeast form of C. albicans cell growth and to the hyphal tip cells in growing filaments. Thus, Ash1p “marks” newly formed cells and presumably directs a specialized transcriptional program in these cells. Finally, we show that ASH1 is required for full virulence of C. albicans in a mouse model of disseminated candidiasis.

  • Copyright © 2002 American Society for Microbiology
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Ash1 Protein, an Asymmetrically Localized Transcriptional Regulator, Controls Filamentous Growth and Virulence of Candida albicans
Diane O. Inglis, Alexander D. Johnson
Molecular and Cellular Biology Dec 2002, 22 (24) 8669-8680; DOI: 10.1128/MCB.22.24.8669-8680.2002

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Ash1 Protein, an Asymmetrically Localized Transcriptional Regulator, Controls Filamentous Growth and Virulence of Candida albicans
Diane O. Inglis, Alexander D. Johnson
Molecular and Cellular Biology Dec 2002, 22 (24) 8669-8680; DOI: 10.1128/MCB.22.24.8669-8680.2002
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KEYWORDS

Candida albicans
transcription factors
Transcription, Genetic

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