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TRANSCRIPTIONAL REGULATION

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

Akira Kobayashi, Moon-Il Kang, Hiromi Okawa, Makiko Ohtsuji, Yukari Zenke, Tomoki Chiba, Kazuhiko Igarashi, Masayuki Yamamoto
Akira Kobayashi
1Center for Tsukuba Advanced Research Alliance
2Institute of Basic Medical Sciences
3JST-ERATO Environmental Response Project University of Tsukuba, Tsukuba 305-8575
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Moon-Il Kang
1Center for Tsukuba Advanced Research Alliance
2Institute of Basic Medical Sciences
3JST-ERATO Environmental Response Project University of Tsukuba, Tsukuba 305-8575
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Hiromi Okawa
1Center for Tsukuba Advanced Research Alliance
2Institute of Basic Medical Sciences
3JST-ERATO Environmental Response Project University of Tsukuba, Tsukuba 305-8575
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Makiko Ohtsuji
1Center for Tsukuba Advanced Research Alliance
2Institute of Basic Medical Sciences
3JST-ERATO Environmental Response Project University of Tsukuba, Tsukuba 305-8575
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Yukari Zenke
4Department of Biomedical Chemistry and Leukemia Program Project, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8551
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Tomoki Chiba
5Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, Bunkyo-Ku, Tokyo 113-8613 Japan
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Kazuhiko Igarashi
4Department of Biomedical Chemistry and Leukemia Program Project, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8551
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Masayuki Yamamoto
1Center for Tsukuba Advanced Research Alliance
2Institute of Basic Medical Sciences
3JST-ERATO Environmental Response Project University of Tsukuba, Tsukuba 305-8575
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  • For correspondence: masi@tara.tsukuba.ac.jp
DOI: 10.1128/MCB.24.16.7130-7139.2004
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Article Information

DOI 
https://doi.org/10.1128/MCB.24.16.7130-7139.2004
PubMed 
15282312

Published By 
American Society for Microbiology Journals
History 
  • Received April 29, 2004
  • Accepted May 20, 2004
  • Published online July 28, 2004.

Copyright & Usage 
Copyright © 2004 American Society for Microbiology

Author Information

  1. Akira Kobayashi1,2,3,
  2. Moon-Il Kang1,2,3,
  3. Hiromi Okawa1,2,3,
  4. Makiko Ohtsuji1,2,3,
  5. Yukari Zenke4,
  6. Tomoki Chiba5,
  7. Kazuhiko Igarashi4 and
  8. Masayuki Yamamoto1,2,3*
  1. 1Center for Tsukuba Advanced Research Alliance
  2. 2Institute of Basic Medical Sciences
  3. 3JST-ERATO Environmental Response Project University of Tsukuba, Tsukuba 305-8575
  4. 4Department of Biomedical Chemistry and Leukemia Program Project, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8551
  5. 5Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, Bunkyo-Ku, Tokyo 113-8613 Japan
  • ↵* Corresponding author. Mailing address: Center for TARA, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan. Phone: 81-29-853-6158. Fax: 81-29-853-7318. E-mail: masi{at}tara.tsukuba.ac.jp .

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Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
Akira Kobayashi, Moon-Il Kang, Hiromi Okawa, Makiko Ohtsuji, Yukari Zenke, Tomoki Chiba, Kazuhiko Igarashi, Masayuki Yamamoto
Molecular and Cellular Biology Jul 2004, 24 (16) 7130-7139; DOI: 10.1128/MCB.24.16.7130-7139.2004

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Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
Akira Kobayashi, Moon-Il Kang, Hiromi Okawa, Makiko Ohtsuji, Yukari Zenke, Tomoki Chiba, Kazuhiko Igarashi, Masayuki Yamamoto
Molecular and Cellular Biology Jul 2004, 24 (16) 7130-7139; DOI: 10.1128/MCB.24.16.7130-7139.2004
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KEYWORDS

Cell Cycle Proteins
Cullin Proteins
Cysteine Endopeptidases
DNA-Binding Proteins
Multienzyme Complexes
oxidative stress
Proteins
Trans-Activators
Ubiquitin-Protein Ligases

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