Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

Akira Kobayashi; Moon-Il Kang; Hiromi Okawa; Makiko Ohtsuji; Yukari Zenke; Tomoki Chiba; Kazuhiko Igarashi; Masayuki Yamamoto

doi:10.1128/MCB.24.16.7130-7139.2004

DOI: 10.1128/MCB.24.16.7130-7139.2004

Article Information

DOI

https://doi.org/10.1128/MCB.24.16.7130-7139.2004

PubMed

15282312

Published By

American Society for Microbiology Journals

History

Received April 29, 2004
Accepted May 20, 2004
Published online July 28, 2004.

Author Information

Akira Kobayashi¹,²,³,
Moon-Il Kang¹,²,³,
Hiromi Okawa¹,²,³,
Makiko Ohtsuji¹,²,³,
Yukari Zenke⁴,
Tomoki Chiba⁵,
Kazuhiko Igarashi⁴ and
Masayuki Yamamoto¹,²,³ *

¹Center for Tsukuba Advanced Research Alliance
²Institute of Basic Medical Sciences
³JST-ERATO Environmental Response Project University of Tsukuba, Tsukuba 305-8575
⁴Department of Biomedical Chemistry and Leukemia Program Project, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8551
⁵Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, Bunkyo-Ku, Tokyo 113-8613 Japan

↵* Corresponding author. Mailing address: Center for TARA, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan. Phone: 81-29-853-6158. Fax: 81-29-853-7318. E-mail: masi{at}tara.tsukuba.ac.jp .

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