Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

Akira Kobayashi; Moon-Il Kang; Hiromi Okawa; Makiko Ohtsuji; Yukari Zenke; Tomoki Chiba; Kazuhiko Igarashi; Masayuki Yamamoto

doi:10.1128/MCB.24.16.7130-7139.2004

DOI: 10.1128/MCB.24.16.7130-7139.2004

Article Information

DOI

https://doi.org/10.1128/MCB.24.16.7130-7139.2004

PubMed

15282312

Published By

American Society for Microbiology Journals

History

Received April 29, 2004
Accepted May 20, 2004
Published online July 28, 2004.

American Society for Microbiology

Author Information

Akira Kobayashi1,2,3,
Moon-Il Kang1,2,3,
Hiromi Okawa1,2,3,
Makiko Ohtsuji1,2,3,
Yukari Zenke4,
Tomoki Chiba5,
Kazuhiko Igarashi4 and
Masayuki Yamamoto1,2,3 *

¹Center for Tsukuba Advanced Research Alliance
²Institute of Basic Medical Sciences
³JST-ERATO Environmental Response Project University of Tsukuba, Tsukuba 305-8575
⁴Department of Biomedical Chemistry and Leukemia Program Project, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8551
⁵Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, Bunkyo-Ku, Tokyo 113-8613 Japan

↵*Corresponding author. Mailing address: Center for TARA, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan. Phone: 81-29-853-6158. Fax: 81-29-853-7318. E-mail: masi{at}tara.tsukuba.ac.jp.

View Abstract

Article usage

Article usage: July 2004 to January 2020

Rendering graph...

	Abstract	Full	Pdf
Jul 2004	146	91	122
Aug 2004	187	557	363
Sep 2004	65	254	135
Oct 2004	42	171	74
Nov 2004	45	144	59
Dec 2004	34	83	47
Jan 2005	12	89	32
Feb 2005	6	74	64
Mar 2005	12	53	60
Apr 2005	5	61	51
May 2005	11	54	46
Jun 2005	10	51	43
Jul 2005	17	62	36
Aug 2005	11	45	35
Sep 2005	13	70	33
Oct 2005	11	57	26
Nov 2005	8	50	14
Dec 2005	14	50	34
Jan 2006	18	57	34
Feb 2006	10	41	22
Mar 2006	11	58	23
Apr 2006	13	114	20
May 2006	22	58	19
Jun 2006	12	55	35
Jul 2006	13	54	24
Aug 2006	17	34	30
Sep 2006	15	33	25
Oct 2006	21	52	43
Nov 2006	13	43	25
Dec 2006	13	27	21
Jan 2007	30	41	36
Feb 2007	8	29	26
Mar 2007	19	29	25
Apr 2007	8	34	195
May 2007	10	32	21
Jun 2007	15	28	25
Jul 2007	21	34	26
Aug 2007	19	40	28
Sep 2007	16	31	21
Oct 2007	30	31	28
Nov 2007	14	26	18
Dec 2007	11	23	13
Jan 2008	30	31	25
Feb 2008	28	34	26
Mar 2008	33	26	20
Apr 2008	41	38	21
May 2008	31	22	17
Jun 2008	26	33	22
Jul 2008	41	44	19
Aug 2008	55	34	16
Sep 2008	20	35	29
Oct 2008	30	39	28
Nov 2008	21	26	17
Dec 2008	19	41	18
Jan 2009	31	41	31
Feb 2009	30	48	24
Mar 2009	52	47	26
Apr 2009	26	30	27
May 2009	36	29	25
Jun 2009	32	44	29
Jul 2009	28	33	22
Aug 2009	24	24	19
Sep 2009	36	25	26
Oct 2009	34	34	38
Nov 2009	52	39	41
Dec 2009	58	22	25
Jan 2010	56	35	34
Feb 2010	24	32	20
Mar 2010	42	31	62
Apr 2010	24	27	16
May 2010	46	22	25
Jun 2010	27	21	22
Jul 2010	35	20	17
Aug 2010	22	19	20
Sep 2010	23	20	21
Oct 2010	29	17	29
Nov 2010	25	27	21
Dec 2010	28	14	23
Jan 2011	49	29	28
Feb 2011	42	25	20
Mar 2011	37	22	40
Apr 2011	34	25	34
May 2011	28	26	28
Jun 2011	38	28	31
Jul 2011	30	32	25
Aug 2011	31	23	26
Sep 2011	40	46	30
Oct 2011	46	28	33
Nov 2011	46	36	20
Dec 2011	37	15	27
Jan 2012	42	52	35
Feb 2012	36	37	26
Mar 2012	42	42	24
Apr 2012	51	41	22
May 2012	45	37	34
Jun 2012	43	37	23
Jul 2012	28	38	28
Aug 2012	35	30	34
Sep 2012	27	31	23
Oct 2012	40	22	27
Nov 2012	41	31	32
Dec 2012	30	24	23
Jan 2013	38	27	24
Feb 2013	58	34	22
Mar 2013	45	25	20
Apr 2013	55	31	25
May 2013	44	21	32
Jun 2013	49	32	39
Jul 2013	57	28	33
Aug 2013	32	26	20
Sep 2013	45	22	26
Oct 2013	35	42	26
Nov 2013	37	47	30
Dec 2013	34	30	18
Jan 2014	41	18	21
Feb 2014	65	22	25
Mar 2014	86	28	31
Apr 2014	59	33	30
May 2014	95	29	22
Jun 2014	80	26	21
Jul 2014	92	23	19
Aug 2014	25	17	20
Sep 2014	35	25	26
Oct 2014	49	42	39
Nov 2014	51	24	21
Dec 2014	31	16	16
Jan 2015	57	40	28
Feb 2015	26	30	20
Mar 2015	48	37	29
Apr 2015	42	25	16
May 2015	58	40	22
Jun 2015	46	25	24
Jul 2015	43	20	24
Aug 2015	66	36	25
Sep 2015	67	28	19
Oct 2015	36	23	25
Nov 2015	47	31	40
Dec 2015	67	19	19
Jan 2016	54	23	22
Feb 2016	71	27	34
Mar 2016	157	39	40
Apr 2016	53	27	18
May 2016	57	45	22
Jun 2016	65	24	25
Jul 2016	67	33	25
Aug 2016	61	44	31
Sep 2016	54	24	34
Oct 2016	92	58	25
Nov 2016	60	30	21
Dec 2016	64	22	15
Jan 2017	59	18	31
Feb 2017	80	20	15
Mar 2017	71	26	25
Apr 2017	52	31	28
May 2017	58	17	24
Jun 2017	49	20	16
Jul 2017	49	13	19
Aug 2017	81	26	19
Sep 2017	57	24	26
Oct 2017	63	33	28
Nov 2017	70	29	29
Dec 2017	59	31	26
Jan 2018	78	30	20
Feb 2018	53	33	33
Mar 2018	71	34	28
Apr 2018	74	22	27
May 2018	67	20	32
Jun 2018	67	15	19
Jul 2018	55	20	22
Aug 2018	34	34	29
Sep 2018	19	66	43
Oct 2018	37	63	32
Nov 2018	29	61	22
Dec 2018	23	238	35
Jan 2019	27	71	41
Feb 2019	21	36	23
Mar 2019	20	65	43
Apr 2019	22	67	39
May 2019	22	58	43
Jun 2019	20	49	26
Jul 2019	27	80	65
Aug 2019	27	62	45
Sep 2019	25	99	50
Oct 2019	15	86	27
Nov 2019	28	67	33
Dec 2019	14	43	27
Jan 2020	18	40	23