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MAMMALIAN GENETIC MODELS WITH MINIMAL OR COMPLEX PHENOTYPES

Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy

Markos Leggas, Masashi Adachi, George L. Scheffer, Daxi Sun, Peter Wielinga, Guoqing Du, Kelly E. Mercer, Yanli Zhuang, John C. Panetta, Brad Johnston, Rik J. Scheper, Clinton F. Stewart, John D. Schuetz
Markos Leggas
1Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
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Masashi Adachi
1Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
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George L. Scheffer
2Department of Pathology, VU Medical Center
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Daxi Sun
1Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
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Peter Wielinga
3Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Guoqing Du
1Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
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Kelly E. Mercer
1Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
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Yanli Zhuang
1Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
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John C. Panetta
1Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
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Brad Johnston
1Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
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Rik J. Scheper
2Department of Pathology, VU Medical Center
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Clinton F. Stewart
1Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
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John D. Schuetz
1Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
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  • For correspondence: John.schuetz@stjude.org
DOI: 10.1128/MCB.24.17.7612-7621.2004
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Article Information

DOI 
https://doi.org/10.1128/MCB.24.17.7612-7621.2004
PubMed 
15314169

Published By 
American Society for Microbiology Journals
History 
  • Received April 6, 2004
  • Returned for modification May 29, 2004
  • Accepted June 12, 2004
  • Published online August 16, 2004.

Copyright & Usage 
Copyright © 2004 American Society for Microbiology

Author Information

  1. Markos Leggas1,
  2. Masashi Adachi1,
  3. George L. Scheffer2,
  4. Daxi Sun1,
  5. Peter Wielinga3,
  6. Guoqing Du1,
  7. Kelly E. Mercer1,
  8. Yanli Zhuang1,
  9. John C. Panetta1,
  10. Brad Johnston1,
  11. Rik J. Scheper2,
  12. Clinton F. Stewart1 and
  13. John D. Schuetz1*
  1. 1Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
  2. 2Department of Pathology, VU Medical Center
  3. 3Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  • ↵* Corresponding author. Mailing address: Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794. Phone: (901) 495-2174. Fax: (901) 525-6869. E-mail: John.schuetz{at}stjude.org .

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Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy
Markos Leggas, Masashi Adachi, George L. Scheffer, Daxi Sun, Peter Wielinga, Guoqing Du, Kelly E. Mercer, Yanli Zhuang, John C. Panetta, Brad Johnston, Rik J. Scheper, Clinton F. Stewart, John D. Schuetz
Molecular and Cellular Biology Aug 2004, 24 (17) 7612-7621; DOI: 10.1128/MCB.24.17.7612-7621.2004

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Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy
Markos Leggas, Masashi Adachi, George L. Scheffer, Daxi Sun, Peter Wielinga, Guoqing Du, Kelly E. Mercer, Yanli Zhuang, John C. Panetta, Brad Johnston, Rik J. Scheper, Clinton F. Stewart, John D. Schuetz
Molecular and Cellular Biology Aug 2004, 24 (17) 7612-7621; DOI: 10.1128/MCB.24.17.7612-7621.2004
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KEYWORDS

Antineoplastic Agents
brain
Multidrug Resistance-Associated Proteins
Topotecan

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