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SIGNAL TRANSDUCTION

A Diacylglycerol-Protein Kinase C-RasGRP1 Pathway Directs Ras Activation upon Antigen Receptor Stimulation of T Cells

Jeroen P. Roose, Marianne Mollenauer, Vikas A. Gupta, James Stone, Arthur Weiss
Jeroen P. Roose
1Departments of Medicine, Microbiology, and Immunology and Howard Hughes Medical Institute
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Marianne Mollenauer
1Departments of Medicine, Microbiology, and Immunology and Howard Hughes Medical Institute
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Vikas A. Gupta
1Departments of Medicine, Microbiology, and Immunology and Howard Hughes Medical Institute
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James Stone
3Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2G7, Canada
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Arthur Weiss
1Departments of Medicine, Microbiology, and Immunology and Howard Hughes Medical Institute
2Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, San Francisco, California 94143
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  • For correspondence: aweiss@medicine.ucsf.edu
DOI: 10.1128/MCB.25.11.4426-4441.2005
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Article Information

DOI 
https://doi.org/10.1128/MCB.25.11.4426-4441.2005
PubMed 
15899849

Published By 
American Society for Microbiology Journals
History 
  • Received October 12, 2004
  • Returned for modification November 10, 2004
  • Accepted March 1, 2005
  • Published online May 16, 2005.

Copyright & Usage 
Copyright © 2005 American Society for Microbiology

Author Information

  1. Jeroen P. Roose1,
  2. Marianne Mollenauer1,
  3. Vikas A. Gupta1,
  4. James Stone3 and
  5. Arthur Weiss1,2*
  1. 1Departments of Medicine, Microbiology, and Immunology and Howard Hughes Medical Institute
  2. 2Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, San Francisco, California 94143
  3. 3Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2G7, Canada
  • ↵* Corresponding author. Mailing address: Departments of Medicine, Microbiology, and Immunology, UCSF, 533 Parnassus Avenue, Room U-330, San Francisco, CA 94143. Phone: (415) 476-1291. Fax: (415) 502-5081. E-mail: aweiss{at}medicine.ucsf.edu .

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A Diacylglycerol-Protein Kinase C-RasGRP1 Pathway Directs Ras Activation upon Antigen Receptor Stimulation of T Cells
Jeroen P. Roose, Marianne Mollenauer, Vikas A. Gupta, James Stone, Arthur Weiss
Molecular and Cellular Biology May 2005, 25 (11) 4426-4441; DOI: 10.1128/MCB.25.11.4426-4441.2005

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A Diacylglycerol-Protein Kinase C-RasGRP1 Pathway Directs Ras Activation upon Antigen Receptor Stimulation of T Cells
Jeroen P. Roose, Marianne Mollenauer, Vikas A. Gupta, James Stone, Arthur Weiss
Molecular and Cellular Biology May 2005, 25 (11) 4426-4441; DOI: 10.1128/MCB.25.11.4426-4441.2005
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KEYWORDS

DNA-Binding Proteins
Diglycerides
Guanine Nucleotide Exchange Factors
Isoenzymes
protein kinase C
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocytes
ras Proteins

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