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CHROMOSOME STRUCTURE AND DYNAMICS

Both V(D)J Coding Ends but Neither Signal End Can Recombine at the bcl-2 Major Breakpoint Region, and the Rejoining Is Ligase IV Dependent

Sathees C. Raghavan, Chih-Lin Hsieh, Michael R. Lieber
Sathees C. Raghavan
1Departments of Pathology, Biochemistry and Molecular Biology, Molecular Microbiology and Immunology, and Biological Sciences
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Chih-Lin Hsieh
2Department of Urology
3Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Ave., Rm. 5428, Los Angeles, California 90089-9176
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Michael R. Lieber
1Departments of Pathology, Biochemistry and Molecular Biology, Molecular Microbiology and Immunology, and Biological Sciences
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  • For correspondence: lieber@usc.edu
DOI: 10.1128/MCB.25.15.6475-6484.2005
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Article Information

DOI 
https://doi.org/10.1128/MCB.25.15.6475-6484.2005
PubMed 
16024785

Published By 
American Society for Microbiology Journals
History 
  • Received February 24, 2005
  • Returned for modification March 31, 2005
  • Accepted April 13, 2005
  • Published online July 15, 2005.

Copyright & Usage 
Copyright © 2005 American Society for Microbiology

Author Information

  1. Sathees C. Raghavan1,
  2. Chih-Lin Hsieh2,3 and
  3. Michael R. Lieber1*
  1. 1Departments of Pathology, Biochemistry and Molecular Biology, Molecular Microbiology and Immunology, and Biological Sciences
  2. 2Department of Urology
  3. 3Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Ave., Rm. 5428, Los Angeles, California 90089-9176
  • ↵* Corresponding author. Mailing address: USC Norris Comprehensive Cancer Ctr., Rm. 5428, 1441 Eastlake Ave., Los Angeles, CA 90089-9176. Phone: (323) 865-0568. Fax: (323) 865-3019. E-mail: lieber{at}usc.edu .

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Both V(D)J Coding Ends but Neither Signal End Can Recombine at the bcl-2 Major Breakpoint Region, and the Rejoining Is Ligase IV Dependent
Sathees C. Raghavan, Chih-Lin Hsieh, Michael R. Lieber
Molecular and Cellular Biology Jul 2005, 25 (15) 6475-6484; DOI: 10.1128/MCB.25.15.6475-6484.2005

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Both V(D)J Coding Ends but Neither Signal End Can Recombine at the bcl-2 Major Breakpoint Region, and the Rejoining Is Ligase IV Dependent
Sathees C. Raghavan, Chih-Lin Hsieh, Michael R. Lieber
Molecular and Cellular Biology Jul 2005, 25 (15) 6475-6484; DOI: 10.1128/MCB.25.15.6475-6484.2005
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KEYWORDS

Chromosome Breakage
DNA Ligases
Gene Rearrangement
Genes, bcl-2
Immunoglobulin Variable Region
Translocation, Genetic

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