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MAMMALIAN GENETIC MODELS WITH MINIMAL OR COMPLEX PHENOTYPES

Phospholipase C-δ1 and -δ3 Are Essential in the Trophoblast for Placental Development

Yoshikazu Nakamura, Yoshio Hamada, Takashi Fujiwara, Hiroko Enomoto, Takeshi Hiroe, Satoshi Tanaka, Masato Nose, Masamichi Nakahara, Nobuaki Yoshida, Tadaomi Takenawa, Kiyoko Fukami
Yoshikazu Nakamura
1Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, 192-0392 Tokyo, Japan
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Yoshio Hamada
2Tissue and Cell Culture Laboratory, National Institute For Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan
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Takashi Fujiwara
3Laboratory Animal Center, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan
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Hiroko Enomoto
1Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, 192-0392 Tokyo, Japan
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Takeshi Hiroe
4Center for Experimental Animals, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki 444-8585, Japan
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Satoshi Tanaka
5Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences/Veterinary Medical Sciences, The University of Tokyo, Yayoi 1-1-1, Bukyo-ku, Tokyo 113-8657, Japan
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Masato Nose
6Department of Pathology, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan
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Masamichi Nakahara
1Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, 192-0392 Tokyo, Japan
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Nobuaki Yoshida
7Division of Gene Expression and Regulation, The Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
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Tadaomi Takenawa
8Department of Biochemistry, The Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
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Kiyoko Fukami
1Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, 192-0392 Tokyo, Japan
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  • For correspondence: kfukami@ls.toyaku.ac.jp
DOI: 10.1128/MCB.25.24.10979-10988.2005
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Article Information

DOI 
https://doi.org/10.1128/MCB.25.24.10979-10988.2005
PubMed 
16314520

Published By 
American Society for Microbiology Journals
History 
  • Received August 19, 2005
  • Returned for modification September 2, 2005
  • Accepted September 18, 2005
  • Published online November 28, 2005.

Copyright & Usage 
Copyright © 2005 American Society for Microbiology

Author Information

  1. Yoshikazu Nakamura1,
  2. Yoshio Hamada2,
  3. Takashi Fujiwara3,
  4. Hiroko Enomoto1,
  5. Takeshi Hiroe4,
  6. Satoshi Tanaka5,
  7. Masato Nose6,
  8. Masamichi Nakahara1,
  9. Nobuaki Yoshida7,
  10. Tadaomi Takenawa8 and
  11. Kiyoko Fukami1*
  1. 1Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, 192-0392 Tokyo, Japan
  2. 2Tissue and Cell Culture Laboratory, National Institute For Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan
  3. 3Laboratory Animal Center, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan
  4. 4Center for Experimental Animals, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki 444-8585, Japan
  5. 5Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences/Veterinary Medical Sciences, The University of Tokyo, Yayoi 1-1-1, Bukyo-ku, Tokyo 113-8657, Japan
  6. 6Department of Pathology, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan
  7. 7Division of Gene Expression and Regulation, The Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
  8. 8Department of Biochemistry, The Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
  • ↵* Corresponding author. Mailing address: Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, 192-0392 Tokyo, Japan. Phone: 81-426-76-7214. Fax: 81-426-76-7249. E-mail: kfukami{at}ls.toyaku.ac.jp .

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Phospholipase C-δ1 and -δ3 Are Essential in the Trophoblast for Placental Development
Yoshikazu Nakamura, Yoshio Hamada, Takashi Fujiwara, Hiroko Enomoto, Takeshi Hiroe, Satoshi Tanaka, Masato Nose, Masamichi Nakahara, Nobuaki Yoshida, Tadaomi Takenawa, Kiyoko Fukami
Molecular and Cellular Biology Nov 2005, 25 (24) 10979-10988; DOI: 10.1128/MCB.25.24.10979-10988.2005

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Phospholipase C-δ1 and -δ3 Are Essential in the Trophoblast for Placental Development
Yoshikazu Nakamura, Yoshio Hamada, Takashi Fujiwara, Hiroko Enomoto, Takeshi Hiroe, Satoshi Tanaka, Masato Nose, Masamichi Nakahara, Nobuaki Yoshida, Tadaomi Takenawa, Kiyoko Fukami
Molecular and Cellular Biology Nov 2005, 25 (24) 10979-10988; DOI: 10.1128/MCB.25.24.10979-10988.2005
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KEYWORDS

Isoenzymes
placenta
Placentation
Trophoblasts
Type C Phospholipases

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