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MAMMALIAN GENETIC MODELS WITH MINIMAL OR COMPLEX PHENOTYPES

TIEG1 Null Mouse-Derived Osteoblasts Are Defective in Mineralization and in Support of Osteoclast Differentiation In Vitro

Malayannan Subramaniam, Genevieve Gorny, Steven A. Johnsen, David G. Monroe, Glenda L. Evans, Daniel G. Fraser, David J. Rickard, Kay Rasmussen, Jan M. A. van Deursen, Russell T. Turner, Merry Jo Oursler, Thomas C. Spelsberg
Malayannan Subramaniam
1Department of Biochemistry and Molecular Biology
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  • For correspondence: subramaniam.malayannan@mayo.edu
Genevieve Gorny
1Department of Biochemistry and Molecular Biology
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Steven A. Johnsen
2Zentrum für Molekulare Neurobiologie, Universität Hamburg, Hamburg, Germany
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David G. Monroe
1Department of Biochemistry and Molecular Biology
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Glenda L. Evans
3Orthopedic Research
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Daniel G. Fraser
4Department of Pediatric and Adolescent Medicine
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David J. Rickard
5Musculoskeletal Diseases Biology, GlaxoSmithKline, Collegeville, Pennsylvania
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Kay Rasmussen
1Department of Biochemistry and Molecular Biology
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Jan M. A. van Deursen
6Division of Endocrinology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota
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Russell T. Turner
3Orthopedic Research
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Merry Jo Oursler
4Department of Pediatric and Adolescent Medicine
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Thomas C. Spelsberg
1Department of Biochemistry and Molecular Biology
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DOI: 10.1128/MCB.25.3.1191-1199.2005
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Article Information

DOI 
https://doi.org/10.1128/MCB.25.3.1191-1199.2005
PubMed 
15657444

Published By 
American Society for Microbiology Journals
History 
  • Received May 25, 2004
  • Returned for modification August 4, 2004
  • Accepted November 4, 2004
  • Published online January 18, 2005.

Copyright & Usage 
Copyright © 2005 American Society for Microbiology

Author Information

  1. Malayannan Subramaniam1*,
  2. Genevieve Gorny1,
  3. Steven A. Johnsen2,
  4. David G. Monroe1,
  5. Glenda L. Evans3,
  6. Daniel G. Fraser4,
  7. David J. Rickard5,
  8. Kay Rasmussen1,
  9. Jan M. A. van Deursen6,
  10. Russell T. Turner3,
  11. Merry Jo Oursler4 and
  12. Thomas C. Spelsberg1
  1. 1Department of Biochemistry and Molecular Biology
  2. 3Orthopedic Research
  3. 4Department of Pediatric and Adolescent Medicine
  4. 6Division of Endocrinology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota
  5. 2Zentrum für Molekulare Neurobiologie, Universität Hamburg, Hamburg, Germany
  6. 5Musculoskeletal Diseases Biology, GlaxoSmithKline, Collegeville, Pennsylvania
  • ↵* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, 1601B Guggenheim Bldg., Mayo Clinic College of Medicine, 200 First St., S.W., Rochester, MN 55905. Phone: (507) 284-4909. Fax: (507) 284-2053. E-mail: subramaniam.malayannan{at}mayo.edu .

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TIEG1 Null Mouse-Derived Osteoblasts Are Defective in Mineralization and in Support of Osteoclast Differentiation In Vitro
Malayannan Subramaniam, Genevieve Gorny, Steven A. Johnsen, David G. Monroe, Glenda L. Evans, Daniel G. Fraser, David J. Rickard, Kay Rasmussen, Jan M. A. van Deursen, Russell T. Turner, Merry Jo Oursler, Thomas C. Spelsberg
Molecular and Cellular Biology Jan 2005, 25 (3) 1191-1199; DOI: 10.1128/MCB.25.3.1191-1199.2005

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TIEG1 Null Mouse-Derived Osteoblasts Are Defective in Mineralization and in Support of Osteoclast Differentiation In Vitro
Malayannan Subramaniam, Genevieve Gorny, Steven A. Johnsen, David G. Monroe, Glenda L. Evans, Daniel G. Fraser, David J. Rickard, Kay Rasmussen, Jan M. A. van Deursen, Russell T. Turner, Merry Jo Oursler, Thomas C. Spelsberg
Molecular and Cellular Biology Jan 2005, 25 (3) 1191-1199; DOI: 10.1128/MCB.25.3.1191-1199.2005
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KEYWORDS

Bone Morphogenetic Proteins
cell differentiation
DNA-Binding Proteins
osteoblasts
Osteoclasts
transcription factors
Transforming Growth Factor beta

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