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Articles

Coordinated Regulation of Toll-Like Receptor and NOD2 Signaling by K63-Linked Polyubiquitin Chains

Derek W. Abbott, Yibin Yang, Jessica E. Hutti, Swetha Madhavarapu, Michelle A. Kelliher, Lewis C. Cantley
Derek W. Abbott
1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio
2Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
3Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Hospital, Boston, Massachusetts
4Department of Systems Biology, Harvard Medical School, Boston, Massachusetts
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  • For correspondence: dwa4@case.edu
Yibin Yang
5Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts
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Jessica E. Hutti
3Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Hospital, Boston, Massachusetts
4Department of Systems Biology, Harvard Medical School, Boston, Massachusetts
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Swetha Madhavarapu
3Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Hospital, Boston, Massachusetts
4Department of Systems Biology, Harvard Medical School, Boston, Massachusetts
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Michelle A. Kelliher
5Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts
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Lewis C. Cantley
3Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Hospital, Boston, Massachusetts
4Department of Systems Biology, Harvard Medical School, Boston, Massachusetts
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DOI: 10.1128/MCB.00270-07
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Article Information

DOI 
https://doi.org/10.1128/MCB.00270-07
PubMed 
17562858

Published By 
American Society for Microbiology Journals
History 
  • Received February 14, 2007
  • Returned for modification April 5, 2007
  • Accepted June 1, 2007
  • Published online August 15, 2007.

Copyright & Usage 
Copyright © 2007 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (June 11, 2007).
  • You are viewing the most recent version of this article.

Author Information

  1. Derek W. Abbott1,2,3,4*,
  2. Yibin Yang5,
  3. Jessica E. Hutti3,4,
  4. Swetha Madhavarapu3,4,
  5. Michelle A. Kelliher5 and
  6. Lewis C. Cantley3,4
  1. 1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio
  2. 2Division of Gastrointestinal Pathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
  3. 3Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Hospital, Boston, Massachusetts
  4. 4Department of Systems Biology, Harvard Medical School, Boston, Massachusetts
  5. 5Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts
  • ↵* Corresponding author. Mailing address: Department of Pathology, Case Western Reserve University School of Medicine, Room 5123 Wolstein Research Building, Cleveland, OH 44106. Phone: (216) 368-8564. Fax: (216) 368-1357. E-mail: dwa4{at}case.edu
  • † Supplemental material for this article may be found at http://mcb.asm.org/ .

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Coordinated Regulation of Toll-Like Receptor and NOD2 Signaling by K63-Linked Polyubiquitin Chains
Derek W. Abbott, Yibin Yang, Jessica E. Hutti, Swetha Madhavarapu, Michelle A. Kelliher, Lewis C. Cantley
Molecular and Cellular Biology Aug 2007, 27 (17) 6012-6025; DOI: 10.1128/MCB.00270-07

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Coordinated Regulation of Toll-Like Receptor and NOD2 Signaling by K63-Linked Polyubiquitin Chains
Derek W. Abbott, Yibin Yang, Jessica E. Hutti, Swetha Madhavarapu, Michelle A. Kelliher, Lewis C. Cantley
Molecular and Cellular Biology Aug 2007, 27 (17) 6012-6025; DOI: 10.1128/MCB.00270-07
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KEYWORDS

Intracellular Signaling Peptides and Proteins
Nod2 Signaling Adaptor Protein
Polyubiquitin
signal transduction
Toll-like receptors

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