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Author's Corrections

Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium

Hai Tao Yuan, Eliyahu V. Khankin, S. Ananth Karumanchi, Samir M. Parikh
Hai Tao Yuan
Division of Molecular and Vascular Medicine, Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215
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Eliyahu V. Khankin
Division of Molecular and Vascular Medicine, Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215
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S. Ananth Karumanchi
Division of Molecular and Vascular Medicine, Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215
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Samir M. Parikh
Division of Molecular and Vascular Medicine, Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215
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DOI: 10.1128/MCB.00466-09
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Volume 29, no. 8, p. 2011-2022, 2009. After publication, we identified an article describing Ang-2 as a weaker activator of Tie-2 than Ang-1 (E. Bogdanovic, V. P. Nguyen, and D. J. Dumont, J. Cell Sci. 119:3551-3560, 2006), leading those authors to propose that Ang-2 may be a partial agonist of the receptor. Our paper confirms this weak agonist activity of exogenous Ang-2 and extends their findings by demonstrating that endogenous Ang-2 is critical for basal Tie-2 activity in cultured ECs and that exogenous Ang-2 inhibits Ang-1-induced Tie-2 activation, thus acting as a partial antagonist as well.

  • Copyright © 2009 American Society for Microbiology
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Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium
Hai Tao Yuan, Eliyahu V. Khankin, S. Ananth Karumanchi, Samir M. Parikh
Molecular and Cellular Biology May 2009, 29 (12) 3451; DOI: 10.1128/MCB.00466-09

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Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium
Hai Tao Yuan, Eliyahu V. Khankin, S. Ananth Karumanchi, Samir M. Parikh
Molecular and Cellular Biology May 2009, 29 (12) 3451; DOI: 10.1128/MCB.00466-09
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KEYWORDS

Angiopoietin-1
Angiopoietin-2
Endothelium, Vascular
Receptor, TIE-2
signal transduction

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