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Articles

Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

Sunil Sudarshan, Carole Sourbier, Hye-Sik Kong, Karen Block, Vladimir A. Valera Romero, Youfeng Yang, Cynthia Galindo, Mehdi Mollapour, Bradley Scroggins, Norman Goode, Min-Jung Lee, Campbell W. Gourlay, Jane Trepel, W. Marston Linehan, Len Neckers
Sunil Sudarshan
1Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892
2Departments of Urology
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Carole Sourbier
1Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892
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Hye-Sik Kong
1Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892
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Karen Block
3Nephrology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78212
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Vladimir A. Valera Romero
1Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892
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Youfeng Yang
1Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892
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Cynthia Galindo
2Departments of Urology
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Mehdi Mollapour
1Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892
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Bradley Scroggins
1Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892
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Norman Goode
1Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892
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Min-Jung Lee
4Medical Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892
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Campbell W. Gourlay
5Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
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Jane Trepel
4Medical Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892
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W. Marston Linehan
1Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892
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Len Neckers
1Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892
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  • For correspondence: neckersl@mail.nih.gov
DOI: 10.1128/MCB.00483-09
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Article Information

DOI 
https://doi.org/10.1128/MCB.00483-09
PubMed 
19470762

Published By 
American Society for Microbiology Journals
History 
  • Received April 14, 2009
  • Accepted May 15, 2009
  • Published online July 13, 2009.

Copyright & Usage 
Copyright © 2009 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (May 26, 2009).
  • You are viewing the most recent version of this article.

Author Information

  1. Sunil Sudarshan1,2,
  2. Carole Sourbier1,
  3. Hye-Sik Kong1,
  4. Karen Block3,
  5. Vladimir A. Valera Romero1,
  6. Youfeng Yang1,
  7. Cynthia Galindo2,
  8. Mehdi Mollapour1,
  9. Bradley Scroggins1,
  10. Norman Goode1,
  11. Min-Jung Lee4,
  12. Campbell W. Gourlay5,
  13. Jane Trepel4,
  14. W. Marston Linehan1 and
  15. Len Neckers1*
  1. 1Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892
  2. 2Departments of Urology
  3. 3Nephrology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78212
  4. 4Medical Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892
  5. 5Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
  • ↵* Corresponding author. Mailing address: Urologic Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892. Phone: (301) 496-5899. Fax: (301) 402-0922. E-mail: neckersl{at}mail.nih.gov

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Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species
Sunil Sudarshan, Carole Sourbier, Hye-Sik Kong, Karen Block, Vladimir A. Valera Romero, Youfeng Yang, Cynthia Galindo, Mehdi Mollapour, Bradley Scroggins, Norman Goode, Min-Jung Lee, Campbell W. Gourlay, Jane Trepel, W. Marston Linehan, Len Neckers
Molecular and Cellular Biology Jul 2009, 29 (15) 4080-4090; DOI: 10.1128/MCB.00483-09

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Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species
Sunil Sudarshan, Carole Sourbier, Hye-Sik Kong, Karen Block, Vladimir A. Valera Romero, Youfeng Yang, Cynthia Galindo, Mehdi Mollapour, Bradley Scroggins, Norman Goode, Min-Jung Lee, Campbell W. Gourlay, Jane Trepel, W. Marston Linehan, Len Neckers
Molecular and Cellular Biology Jul 2009, 29 (15) 4080-4090; DOI: 10.1128/MCB.00483-09
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KEYWORDS

Fumarate Hydratase
glucose
glycolysis
Hypoxia-Inducible Factor 1, alpha Subunit
reactive oxygen species

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