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Articles

NF2/Merlin Is a Novel Negative Regulator of mTOR Complex 1, and Activation of mTORC1 Is Associated with Meningioma and Schwannoma Growth

Marianne F. James, Sangyeul Han, Carolyn Polizzano, Scott R. Plotkin, Brendan D. Manning, Anat O. Stemmer-Rachamimov, James F. Gusella, Vijaya Ramesh
Marianne F. James
1Center for Human Genetic Research, Massachusetts General Hospital, Richard B. Simches Research Building, 185 Cambridge Street, Boston, Massachusetts 02114
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Sangyeul Han
1Center for Human Genetic Research, Massachusetts General Hospital, Richard B. Simches Research Building, 185 Cambridge Street, Boston, Massachusetts 02114
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Carolyn Polizzano
1Center for Human Genetic Research, Massachusetts General Hospital, Richard B. Simches Research Building, 185 Cambridge Street, Boston, Massachusetts 02114
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Scott R. Plotkin
2Department of Neurology
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Brendan D. Manning
3Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115
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Anat O. Stemmer-Rachamimov
4Molecular Neuro-Oncology Laboratory, Division of Neuropathology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts
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James F. Gusella
1Center for Human Genetic Research, Massachusetts General Hospital, Richard B. Simches Research Building, 185 Cambridge Street, Boston, Massachusetts 02114
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Vijaya Ramesh
1Center for Human Genetic Research, Massachusetts General Hospital, Richard B. Simches Research Building, 185 Cambridge Street, Boston, Massachusetts 02114
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  • For correspondence: ramesh@helix.mgh.harvard.edu
DOI: 10.1128/MCB.01581-08
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Article Information

DOI 
https://doi.org/10.1128/MCB.01581-08
PubMed 
19451225

Published By 
American Society for Microbiology Journals
History 
  • Received October 8, 2008
  • Returned for modification January 7, 2009
  • Accepted May 12, 2009
  • Published online July 13, 2009.

Copyright & Usage 
Copyright © 2009 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (May 18, 2009).
  • You are viewing the most recent version of this article.

Author Information

  1. Marianne F. James1,
  2. Sangyeul Han1,
  3. Carolyn Polizzano1,
  4. Scott R. Plotkin2,
  5. Brendan D. Manning3,
  6. Anat O. Stemmer-Rachamimov4,
  7. James F. Gusella1 and
  8. Vijaya Ramesh1*
  1. 1Center for Human Genetic Research, Massachusetts General Hospital, Richard B. Simches Research Building, 185 Cambridge Street, Boston, Massachusetts 02114
  2. 2Department of Neurology
  3. 4Molecular Neuro-Oncology Laboratory, Division of Neuropathology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts
  4. 3Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115
  • ↵* Corresponding author. Mailing address: Center for Human Genetic Research, Massachusetts General Hospital, Richard B. Simches Research Building, 185 Cambridge St., Boston, MA 02114. Phone: (617) 724-9733. Fax: (617) 726-3655. E-mail: ramesh{at}helix.mgh.harvard.edu
  • † Supplemental material for this article may be found at http://mcb.asm.org/ .

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NF2/Merlin Is a Novel Negative Regulator of mTOR Complex 1, and Activation of mTORC1 Is Associated with Meningioma and Schwannoma Growth
Marianne F. James, Sangyeul Han, Carolyn Polizzano, Scott R. Plotkin, Brendan D. Manning, Anat O. Stemmer-Rachamimov, James F. Gusella, Vijaya Ramesh
Molecular and Cellular Biology Jul 2009, 29 (15) 4250-4261; DOI: 10.1128/MCB.01581-08

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NF2/Merlin Is a Novel Negative Regulator of mTOR Complex 1, and Activation of mTORC1 Is Associated with Meningioma and Schwannoma Growth
Marianne F. James, Sangyeul Han, Carolyn Polizzano, Scott R. Plotkin, Brendan D. Manning, Anat O. Stemmer-Rachamimov, James F. Gusella, Vijaya Ramesh
Molecular and Cellular Biology Jul 2009, 29 (15) 4250-4261; DOI: 10.1128/MCB.01581-08
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KEYWORDS

cell proliferation
Neurofibromin 2
transcription factors

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