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Articles

Peroxisome Proliferator-Activated Receptor β/δ (PPARβ/δ) but Not PPARα Serves as a Plasma Free Fatty Acid Sensor in Liver

Linda M. Sanderson, Tatjana Degenhardt, Arjen Koppen, Eric Kalkhoven, Beatrice Desvergne, Michael Müller, Sander Kersten
Linda M. Sanderson
1Nutrigenomics Consortium, TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, The Netherlands
2Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
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Tatjana Degenhardt
3Department of Biochemistry, University of Kuopio, 70211 Kuopio, Finland
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Arjen Koppen
4Departments of Metabolic and Endocrine Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands
5Netherlands Metabolomics Center, Leiden, The Netherlands
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Eric Kalkhoven
4Departments of Metabolic and Endocrine Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands
5Netherlands Metabolomics Center, Leiden, The Netherlands
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Beatrice Desvergne
6 Centre Intégrative Génomique, University of Lausanne, Lausanne, Switzerland
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Michael Müller
1Nutrigenomics Consortium, TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, The Netherlands
2Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
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Sander Kersten
1Nutrigenomics Consortium, TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, The Netherlands
2Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
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  • For correspondence: sander.kersten@wur.nl
DOI: 10.1128/MCB.00370-09
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Article Information

DOI 
https://doi.org/10.1128/MCB.00370-09
PubMed 
19805517

Published By 
American Society for Microbiology Journals
History 
  • Received March 23, 2009
  • Returned for modification April 26, 2009
  • Accepted September 14, 2009
  • Published online November 6, 2009.

Copyright & Usage 
Copyright © 2009 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (October 05, 2009).
  • You are viewing the most recent version of this article.

Author Information

  1. Linda M. Sanderson1,2,
  2. Tatjana Degenhardt3,
  3. Arjen Koppen4,5,
  4. Eric Kalkhoven4,5,
  5. Beatrice Desvergne6,
  6. Michael Müller1,2 and
  7. Sander Kersten1,2*
  1. 1Nutrigenomics Consortium, TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, The Netherlands
  2. 2Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
  3. 3Department of Biochemistry, University of Kuopio, 70211 Kuopio, Finland
  4. 4Departments of Metabolic and Endocrine Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands
  5. 5Netherlands Metabolomics Center, Leiden, The Netherlands
  6. 6 Centre Intégrative Génomique, University of Lausanne, Lausanne, Switzerland
  • ↵* Corresponding author. Mailing address: Nutrition, Metabolism and Genomics Group, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands. Phone: 31 317 485787. Fax: 31 317 483342. E-mail: sander.kersten{at}wur.nl
  • † Supplemental material for this article may be found at http://mcb.asm.org/ .

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Peroxisome Proliferator-Activated Receptor β/δ (PPARβ/δ) but Not PPARα Serves as a Plasma Free Fatty Acid Sensor in Liver
Linda M. Sanderson, Tatjana Degenhardt, Arjen Koppen, Eric Kalkhoven, Beatrice Desvergne, Michael Müller, Sander Kersten
Molecular and Cellular Biology Nov 2009, 29 (23) 6257-6267; DOI: 10.1128/MCB.00370-09

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Peroxisome Proliferator-Activated Receptor β/δ (PPARβ/δ) but Not PPARα Serves as a Plasma Free Fatty Acid Sensor in Liver
Linda M. Sanderson, Tatjana Degenhardt, Arjen Koppen, Eric Kalkhoven, Beatrice Desvergne, Michael Müller, Sander Kersten
Molecular and Cellular Biology Nov 2009, 29 (23) 6257-6267; DOI: 10.1128/MCB.00370-09
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KEYWORDS

Fatty Acids
liver
PPAR alpha
PPAR-beta
Receptors, Cytoplasmic and Nuclear

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