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Articles

The Ku80 Carboxy Terminus Stimulates Joining and Artemis-Mediated Processing of DNA Ends

Eric Weterings, Nicole S. Verkaik, Guido Keijzers, Bogdan I. Florea, Shih-Ya Wang, Laura G. Ortega, Naoya Uematsu, David J. Chen, Dik C. van Gent
Eric Weterings
1Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, Dallas, Texas 75390-9187
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Nicole S. Verkaik
2Department of Cell Biology and Genetics, Erasmus MC, University Medical Center, Dr. Molewaterplein 50, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
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Guido Keijzers
2Department of Cell Biology and Genetics, Erasmus MC, University Medical Center, Dr. Molewaterplein 50, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
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Bogdan I. Florea
2Department of Cell Biology and Genetics, Erasmus MC, University Medical Center, Dr. Molewaterplein 50, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
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Shih-Ya Wang
1Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, Dallas, Texas 75390-9187
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Laura G. Ortega
1Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, Dallas, Texas 75390-9187
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Naoya Uematsu
1Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, Dallas, Texas 75390-9187
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David J. Chen
1Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, Dallas, Texas 75390-9187
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  • For correspondence: david.chen@utsouthwestern.edu d.vangent@erasmusmc.nl
Dik C. van Gent
2Department of Cell Biology and Genetics, Erasmus MC, University Medical Center, Dr. Molewaterplein 50, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
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  • For correspondence: david.chen@utsouthwestern.edu d.vangent@erasmusmc.nl
DOI: 10.1128/MCB.00971-08
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Article Information

DOI 
https://doi.org/10.1128/MCB.00971-08
PubMed 
19103741

Published By 
American Society for Microbiology Journals
History 
  • Received June 19, 2008
  • Returned for modification July 24, 2008
  • Accepted December 2, 2008
  • Published online February 11, 2009.

Copyright & Usage 
Copyright © 2009 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (December 22, 2008).
  • You are viewing the most recent version of this article.

Author Information

  1. Eric Weterings1†,
  2. Nicole S. Verkaik2†,
  3. Guido Keijzers2†,
  4. Bogdan I. Florea2,
  5. Shih-Ya Wang1,
  6. Laura G. Ortega1,
  7. Naoya Uematsu1,
  8. David J. Chen1* and
  9. Dik C. van Gent2*
  1. 1Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, Dallas, Texas 75390-9187
  2. 2Department of Cell Biology and Genetics, Erasmus MC, University Medical Center, Dr. Molewaterplein 50, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
  • ↵† E.W., N.S.V., and G.K. contributed equally to this study.

  • ↵* Corresponding author. Mailing address for David J. Chen: Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9187. Phone: (214) 648-5597. Fax: (214) 648-5995. E-mail: david.chen{at}utsouthwestern.edu . Mailing address for Dik C. van Gent: Department of Cell Biology and Genetics, Erasmus MC, University Medical Center, Dr. Molewaterplein 50, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. Phone: 31-10-4087932. Fax: 31-10-4089468. E-mail: d.vangent{at}erasmusmc.nl

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The Ku80 Carboxy Terminus Stimulates Joining and Artemis-Mediated Processing of DNA Ends
Eric Weterings, Nicole S. Verkaik, Guido Keijzers, Bogdan I. Florea, Shih-Ya Wang, Laura G. Ortega, Naoya Uematsu, David J. Chen, Dik C. van Gent
Molecular and Cellular Biology Feb 2009, 29 (5) 1134-1142; DOI: 10.1128/MCB.00971-08

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The Ku80 Carboxy Terminus Stimulates Joining and Artemis-Mediated Processing of DNA Ends
Eric Weterings, Nicole S. Verkaik, Guido Keijzers, Bogdan I. Florea, Shih-Ya Wang, Laura G. Ortega, Naoya Uematsu, David J. Chen, Dik C. van Gent
Molecular and Cellular Biology Feb 2009, 29 (5) 1134-1142; DOI: 10.1128/MCB.00971-08
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KEYWORDS

Antigens, Nuclear
DNA-Binding Proteins
Nuclear Proteins
Sequence Deletion

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