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Articles

The Gene for Aromatase, a Rate-Limiting Enzyme for Local Estrogen Biosynthesis, Is a Downstream Target Gene of Runx2 in Skeletal Tissues

Jae-Hwan Jeong, Youn-Kwan Jung, Hyo-Jin Kim, Jung-Sook Jin, Hyun-Nam Kim, Sang-Min Kang, Shin-Yoon Kim, Andre J. van Wijnen, Janet L. Stein, Jane B. Lian, Gary S. Stein, Shigeaki Kato, Je-Yong Choi
Jae-Hwan Jeong
1Department of Biochemistry and Cell Biology, School of Medicine
2Skeletal Diseases Genome Research Center, WCU Program, Kyungpook National University, Daegu 700-422, Republic of Korea
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Youn-Kwan Jung
1Department of Biochemistry and Cell Biology, School of Medicine
2Skeletal Diseases Genome Research Center, WCU Program, Kyungpook National University, Daegu 700-422, Republic of Korea
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Hyo-Jin Kim
1Department of Biochemistry and Cell Biology, School of Medicine
2Skeletal Diseases Genome Research Center, WCU Program, Kyungpook National University, Daegu 700-422, Republic of Korea
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Jung-Sook Jin
1Department of Biochemistry and Cell Biology, School of Medicine
2Skeletal Diseases Genome Research Center, WCU Program, Kyungpook National University, Daegu 700-422, Republic of Korea
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Hyun-Nam Kim
1Department of Biochemistry and Cell Biology, School of Medicine
2Skeletal Diseases Genome Research Center, WCU Program, Kyungpook National University, Daegu 700-422, Republic of Korea
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Sang-Min Kang
1Department of Biochemistry and Cell Biology, School of Medicine
2Skeletal Diseases Genome Research Center, WCU Program, Kyungpook National University, Daegu 700-422, Republic of Korea
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Shin-Yoon Kim
2Skeletal Diseases Genome Research Center, WCU Program, Kyungpook National University, Daegu 700-422, Republic of Korea
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Andre J. van Wijnen
3Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655
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Janet L. Stein
3Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655
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Jane B. Lian
3Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655
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Gary S. Stein
3Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655
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Shigeaki Kato
4Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
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Je-Yong Choi
1Department of Biochemistry and Cell Biology, School of Medicine
2Skeletal Diseases Genome Research Center, WCU Program, Kyungpook National University, Daegu 700-422, Republic of Korea
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  • For correspondence: jechoi@knu.ac.kr
DOI: 10.1128/MCB.00672-09
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Article Information

DOI 
https://doi.org/10.1128/MCB.00672-09
PubMed 
20231365

Published By 
American Society for Microbiology Journals
History 
  • Received May 25, 2009
  • Returned for modification June 23, 2009
  • Accepted March 1, 2010
  • Published online April 26, 2010.

Copyright & Usage 
Copyright © 2010 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (March 15, 2010).
  • You are viewing the most recent version of this article.

Author Information

  1. Jae-Hwan Jeong1,2,
  2. Youn-Kwan Jung1,2,
  3. Hyo-Jin Kim1,2,
  4. Jung-Sook Jin1,2,
  5. Hyun-Nam Kim1,2,
  6. Sang-Min Kang1,2,
  7. Shin-Yoon Kim2,
  8. Andre J. van Wijnen3,
  9. Janet L. Stein3,
  10. Jane B. Lian3,
  11. Gary S. Stein3,
  12. Shigeaki Kato4 and
  13. Je-Yong Choi1,2*
  1. 1Department of Biochemistry and Cell Biology, School of Medicine
  2. 2Skeletal Diseases Genome Research Center, WCU Program, Kyungpook National University, Daegu 700-422, Republic of Korea
  3. 3Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655
  4. 4Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
  • ↵* Corresponding author. Mailing address: Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, 101 Dongin-Dong, Jung-Gu, Daegu 700-422, Republic of Korea. Phone: 82-53-420-4823. Fax: 82-53-422-1466. E-mail: jechoi{at}knu.ac.kr

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The Gene for Aromatase, a Rate-Limiting Enzyme for Local Estrogen Biosynthesis, Is a Downstream Target Gene of Runx2 in Skeletal Tissues
Jae-Hwan Jeong, Youn-Kwan Jung, Hyo-Jin Kim, Jung-Sook Jin, Hyun-Nam Kim, Sang-Min Kang, Shin-Yoon Kim, Andre J. van Wijnen, Janet L. Stein, Jane B. Lian, Gary S. Stein, Shigeaki Kato, Je-Yong Choi
Molecular and Cellular Biology Apr 2010, 30 (10) 2365-2375; DOI: 10.1128/MCB.00672-09

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The Gene for Aromatase, a Rate-Limiting Enzyme for Local Estrogen Biosynthesis, Is a Downstream Target Gene of Runx2 in Skeletal Tissues
Jae-Hwan Jeong, Youn-Kwan Jung, Hyo-Jin Kim, Jung-Sook Jin, Hyun-Nam Kim, Sang-Min Kang, Shin-Yoon Kim, Andre J. van Wijnen, Janet L. Stein, Jane B. Lian, Gary S. Stein, Shigeaki Kato, Je-Yong Choi
Molecular and Cellular Biology Apr 2010, 30 (10) 2365-2375; DOI: 10.1128/MCB.00672-09
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KEYWORDS

Aromatase
Bone and Bones
Core Binding Factor Alpha 1 Subunit
Estrogens
Gene Expression Regulation, Enzymologic

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