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Articles

Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells

Jaclyn S. Long, Joanne Edwards, Carol Watson, Sian Tovey, Kirsty M. Mair, Rachel Schiff, Viswanathan Natarajan, Nigel J. Pyne, Susan Pyne
Jaclyn S. Long
1Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor St., Glasgow G4 0NR, United Kingdom
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Joanne Edwards
2Section of Surgery, Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, Glasgow Royal Infirmary, University of Glasgow, Glasgow G31 2ER, United Kingdom
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Carol Watson
2Section of Surgery, Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, Glasgow Royal Infirmary, University of Glasgow, Glasgow G31 2ER, United Kingdom
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Sian Tovey
2Section of Surgery, Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, Glasgow Royal Infirmary, University of Glasgow, Glasgow G31 2ER, United Kingdom
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Kirsty M. Mair
1Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor St., Glasgow G4 0NR, United Kingdom
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Rachel Schiff
3Breast Center, MS:BCM 600, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030
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Viswanathan Natarajan
4Department of Pharmacology, University of Illinois at Chicago, South Wolcott Ave., Chicago, Illinois 60612
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Nigel J. Pyne
1Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor St., Glasgow G4 0NR, United Kingdom
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  • For correspondence: susan.pyne@strath.ac.uk n.j.pyne@strath.ac.uk
Susan Pyne
1Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor St., Glasgow G4 0NR, United Kingdom
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  • For correspondence: susan.pyne@strath.ac.uk n.j.pyne@strath.ac.uk
DOI: 10.1128/MCB.01133-09
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Article Information

DOI 
https://doi.org/10.1128/MCB.01133-09
PubMed 
20516217

Published By 
American Society for Microbiology Journals
History 
  • Received August 20, 2009
  • Returned for modification November 5, 2009
  • Accepted May 13, 2010
  • Published online July 9, 2010.

Copyright & Usage 
Copyright © 2010 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (June 01, 2010).
  • You are viewing the most recent version of this article.

Author Information

  1. Jaclyn S. Long1,
  2. Joanne Edwards2,
  3. Carol Watson2,
  4. Sian Tovey2,
  5. Kirsty M. Mair1,
  6. Rachel Schiff3,
  7. Viswanathan Natarajan4,
  8. Nigel J. Pyne1* and
  9. Susan Pyne1*
  1. 1Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor St., Glasgow G4 0NR, United Kingdom
  2. 2Section of Surgery, Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, Glasgow Royal Infirmary, University of Glasgow, Glasgow G31 2ER, United Kingdom
  3. 3Breast Center, MS:BCM 600, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030
  4. 4Department of Pharmacology, University of Illinois at Chicago, South Wolcott Ave., Chicago, Illinois 60612
  • ↵* Corresponding author. Mailing address: Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor St., Glasgow G4 0NR, United Kingdom. Phone for Susan Pyne: 44-141 548 2012. Fax: 44-141 552 2562. E-mail: susan.pyne{at}strath.ac.uk . Phone for Nigel J. Pyne: 44-141 548 2659. Fax: 44-141 552 2562. E-mail: n.j.pyne{at}strath.ac.uk

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Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells
Jaclyn S. Long, Joanne Edwards, Carol Watson, Sian Tovey, Kirsty M. Mair, Rachel Schiff, Viswanathan Natarajan, Nigel J. Pyne, Susan Pyne
Molecular and Cellular Biology Jul 2010, 30 (15) 3827-3841; DOI: 10.1128/MCB.01133-09

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Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells
Jaclyn S. Long, Joanne Edwards, Carol Watson, Sian Tovey, Kirsty M. Mair, Rachel Schiff, Viswanathan Natarajan, Nigel J. Pyne, Susan Pyne
Molecular and Cellular Biology Jul 2010, 30 (15) 3827-3841; DOI: 10.1128/MCB.01133-09
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KEYWORDS

Breast Neoplasms
ErbB Receptors
Receptors, Estrogen

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