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Articles

Renal Oxygenation Suppresses VHL Loss-Induced Senescence That Is Caused by Increased Sensitivity to Oxidative Stress

Scott M. Welford, Mary Jo Dorie, Xiaofeng Li, Volker H. Haase, Amato J. Giaccia
Scott M. Welford
1Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305
2Department of Radiation Oncology, Case Western Reserve University, Cleveland, Ohio 44106
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Mary Jo Dorie
1Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305
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Xiaofeng Li
2Department of Radiation Oncology, Case Western Reserve University, Cleveland, Ohio 44106
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Volker H. Haase
3Departments of Medicine, Cancer Biology, Molecular Physiology, and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
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Amato J. Giaccia
1Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305
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  • For correspondence: giaccia@stanford.edu
DOI: 10.1128/MCB.01618-09
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Article Information

DOI 
https://doi.org/10.1128/MCB.01618-09
PubMed 
20679489

Published By 
American Society for Microbiology Journals
History 
  • Received December 16, 2009
  • Returned for modification March 16, 2010
  • Accepted July 6, 2010
  • Published online September 9, 2010.

Copyright & Usage 
Copyright © 2010 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (August 02, 2010).
  • You are viewing the most recent version of this article.

Author Information

  1. Scott M. Welford1,2,
  2. Mary Jo Dorie1,
  3. Xiaofeng Li2,
  4. Volker H. Haase3 and
  5. Amato J. Giaccia1*
  1. 1Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305
  2. 2Department of Radiation Oncology, Case Western Reserve University, Cleveland, Ohio 44106
  3. 3Departments of Medicine, Cancer Biology, Molecular Physiology, and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
  • ↵* Corresponding author. Mailing address: Department of Radiation Oncology, Stanford University School of Medicine, 1235 CCSR, 269 Campus Drive, Stanford, CA 93025. Phone: (650) 723-7311. Fax: (650) 723-7382. E-mail: giaccia{at}stanford.edu
  • † Supplemental material for this article may be found at http://mcb.asm.org/ .

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Renal Oxygenation Suppresses VHL Loss-Induced Senescence That Is Caused by Increased Sensitivity to Oxidative Stress
Scott M. Welford, Mary Jo Dorie, Xiaofeng Li, Volker H. Haase, Amato J. Giaccia
Molecular and Cellular Biology Sep 2010, 30 (19) 4595-4603; DOI: 10.1128/MCB.01618-09

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Renal Oxygenation Suppresses VHL Loss-Induced Senescence That Is Caused by Increased Sensitivity to Oxidative Stress
Scott M. Welford, Mary Jo Dorie, Xiaofeng Li, Volker H. Haase, Amato J. Giaccia
Molecular and Cellular Biology Sep 2010, 30 (19) 4595-4603; DOI: 10.1128/MCB.01618-09
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KEYWORDS

Cellular Senescence
kidney
oxidative stress
Von Hippel-Lindau Tumor Suppressor Protein

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