Peroxisome Proliferator-Activated Receptor β/δ (PPARβ/δ) but Not PPARα Serves as a Plasma Free Fatty Acid Sensor in Liver

Nutrigenomics Consortium, TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, the Netherlands; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, the Netherlands; Department of Biochemistry, University of Kuopio, 70211 Kuopio, Finland; Departments of Metabolic and Endocrine Diseases, University Medical Centre Utrecht, Utrecht, the Netherlands; Netherlands Metabolomics Center, Leiden, the Netherlands; and Centre Intégrative Génomique, University of Lausanne, Lausanne, Switzerland

Nutrigenomics Consortium, TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, the Netherlands; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, the Netherlands; Department of Biochemistry, University of Kuopio, 70211 Kuopio, Finland; Departments of Metabolic and Endocrine Diseases, University Medical Centre Utrecht, Utrecht, the Netherlands; Netherlands Metabolomics Center, Leiden, the Netherlands; and Centre Intégrative Génomique, University of Lausanne, Lausanne, Switzerland

Nutrigenomics Consortium, TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, the Netherlands; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, the Netherlands; Department of Biochemistry, University of Kuopio, 70211 Kuopio, Finland; Departments of Metabolic and Endocrine Diseases, University Medical Centre Utrecht, Utrecht, the Netherlands; Netherlands Metabolomics Center, Leiden, the Netherlands; and Centre Intégrative Génomique, University of Lausanne, Lausanne, Switzerland

Nutrigenomics Consortium, TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, the Netherlands; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, the Netherlands; Department of Biochemistry, University of Kuopio, 70211 Kuopio, Finland; Departments of Metabolic and Endocrine Diseases, University Medical Centre Utrecht, Utrecht, the Netherlands; Netherlands Metabolomics Center, Leiden, the Netherlands; and Centre Intégrative Génomique, University of Lausanne, Lausanne, Switzerland

Nutrigenomics Consortium, TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, the Netherlands; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, the Netherlands; Department of Biochemistry, University of Kuopio, 70211 Kuopio, Finland; Departments of Metabolic and Endocrine Diseases, University Medical Centre Utrecht, Utrecht, the Netherlands; Netherlands Metabolomics Center, Leiden, the Netherlands; and Centre Intégrative Génomique, University of Lausanne, Lausanne, Switzerland

Nutrigenomics Consortium, TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, the Netherlands; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, the Netherlands; Department of Biochemistry, University of Kuopio, 70211 Kuopio, Finland; Departments of Metabolic and Endocrine Diseases, University Medical Centre Utrecht, Utrecht, the Netherlands; Netherlands Metabolomics Center, Leiden, the Netherlands; and Centre Intégrative Génomique, University of Lausanne, Lausanne, Switzerland

Nutrigenomics Consortium, TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, the Netherlands; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, the Netherlands; Department of Biochemistry, University of Kuopio, 70211 Kuopio, Finland; Departments of Metabolic and Endocrine Diseases, University Medical Centre Utrecht, Utrecht, the Netherlands; Netherlands Metabolomics Center, Leiden, the Netherlands; and Centre Intégrative Génomique, University of Lausanne, Lausanne, Switzerland