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Articles

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

Masahiro Morita, Lian Wee Ler, Marc R. Fabian, Nadeem Siddiqui, Michael Mullin, Valerie C. Henderson, Tommy Alain, Bruno D. Fonseca, Galina Karashchuk, Christopher F. Bennett, Tomohiro Kabuta, Shinji Higashi, Ola Larsson, Ivan Topisirovic, Robert J. Smith, Anne-Claude Gingras, Nahum Sonenberg
Masahiro Morita
aDepartment of Biochemistry and Goodman Cancer Research Centre, McGill University, Montréal, Quebec, Canada
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Lian Wee Ler
aDepartment of Biochemistry and Goodman Cancer Research Centre, McGill University, Montréal, Quebec, Canada
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Marc R. Fabian
aDepartment of Biochemistry and Goodman Cancer Research Centre, McGill University, Montréal, Quebec, Canada
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Nadeem Siddiqui
aDepartment of Biochemistry and Goodman Cancer Research Centre, McGill University, Montréal, Quebec, Canada
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Michael Mullin
bSamuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
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Valerie C. Henderson
aDepartment of Biochemistry and Goodman Cancer Research Centre, McGill University, Montréal, Quebec, Canada
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Tommy Alain
aDepartment of Biochemistry and Goodman Cancer Research Centre, McGill University, Montréal, Quebec, Canada
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Bruno D. Fonseca
aDepartment of Biochemistry and Goodman Cancer Research Centre, McGill University, Montréal, Quebec, Canada
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Galina Karashchuk
cDepartment of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, USA
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Christopher F. Bennett
aDepartment of Biochemistry and Goodman Cancer Research Centre, McGill University, Montréal, Quebec, Canada
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Tomohiro Kabuta
dDepartment of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira-shi, Tokyo, Japan
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Shinji Higashi
eDementis Research Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan
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Ola Larsson
fDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden
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Ivan Topisirovic
gLady Davis Institute for Medical Research, SMBD-Jewish General Hospital, McGill University, Montréal, Quebec, Canada
hDepartment of Oncology, McGill University, Montréal, Quebec, Canada
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Robert J. Smith
iDepartment of Veterans Affairs Medical Center, Alpert Medical School of Brown University, Providence, Rhode Island, USA
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Anne-Claude Gingras
bSamuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
jDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
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Nahum Sonenberg
aDepartment of Biochemistry and Goodman Cancer Research Centre, McGill University, Montréal, Quebec, Canada
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DOI: 10.1128/MCB.00455-12
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Article Information

DOI 
https://doi.org/10.1128/MCB.00455-12
PubMed 
22751931

Published By 
American Society for Microbiology Journals
History 
  • Received April 11, 2012
  • Returned for modification May 1, 2012
  • Accepted June 26, 2012
  • Published online August 13, 2012.

Copyright & Usage 
Copyright © 2012, American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (July 02, 2012).
  • You are viewing the most recent version of this article.

Author Information

  1. Masahiro Moritaa,
  2. Lian Wee Lera,
  3. Marc R. Fabiana,
  4. Nadeem Siddiquia,
  5. Michael Mullinb,
  6. Valerie C. Hendersona,
  7. Tommy Alaina,
  8. Bruno D. Fonsecaa,
  9. Galina Karashchukc,
  10. Christopher F. Bennetta,
  11. Tomohiro Kabutad,
  12. Shinji Higashie,
  13. Ola Larssonf,
  14. Ivan Topisirovicg,h,
  15. Robert J. Smithi,
  16. Anne-Claude Gingrasb,j and
  17. Nahum Sonenberga
  1. aDepartment of Biochemistry and Goodman Cancer Research Centre, McGill University, Montréal, Quebec, Canada
  2. bSamuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
  3. cDepartment of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, USA
  4. dDepartment of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira-shi, Tokyo, Japan
  5. eDementis Research Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan
  6. fDepartment of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden
  7. gLady Davis Institute for Medical Research, SMBD-Jewish General Hospital, McGill University, Montréal, Quebec, Canada
  8. hDepartment of Oncology, McGill University, Montréal, Quebec, Canada
  9. iDepartment of Veterans Affairs Medical Center, Alpert Medical School of Brown University, Providence, Rhode Island, USA
  10. jDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
  • Address correspondence to Nahum Sonenberg, nahum.sonenberg{at}mcgill.ca.
  • M.M. and L.W.L. contributed equally to this article.

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A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development
Masahiro Morita, Lian Wee Ler, Marc R. Fabian, Nadeem Siddiqui, Michael Mullin, Valerie C. Henderson, Tommy Alain, Bruno D. Fonseca, Galina Karashchuk, Christopher F. Bennett, Tomohiro Kabuta, Shinji Higashi, Ola Larsson, Ivan Topisirovic, Robert J. Smith, Anne-Claude Gingras, Nahum Sonenberg
Molecular and Cellular Biology Aug 2012, 32 (17) 3585-3593; DOI: 10.1128/MCB.00455-12

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A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development
Masahiro Morita, Lian Wee Ler, Marc R. Fabian, Nadeem Siddiqui, Michael Mullin, Valerie C. Henderson, Tommy Alain, Bruno D. Fonseca, Galina Karashchuk, Christopher F. Bennett, Tomohiro Kabuta, Shinji Higashi, Ola Larsson, Ivan Topisirovic, Robert J. Smith, Anne-Claude Gingras, Nahum Sonenberg
Molecular and Cellular Biology Aug 2012, 32 (17) 3585-3593; DOI: 10.1128/MCB.00455-12
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