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Articles

SIRT4 Represses Peroxisome Proliferator-Activated Receptor α Activity To Suppress Hepatic Fat Oxidation

Gaëlle Laurent, Vincent C. J. de Boer, Lydia W. S. Finley, Meredith Sweeney, Hong Lu, Thaddeus T. Schug, Yana Cen, Seung Min Jeong, Xiaoling Li, Anthony A. Sauve, Marcia C. Haigis
Gaëlle Laurent
aDepartment of Cell Biology, The Paul F. Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, Massachusetts, USA
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Vincent C. J. de Boer
aDepartment of Cell Biology, The Paul F. Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, Massachusetts, USA
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Lydia W. S. Finley
aDepartment of Cell Biology, The Paul F. Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, Massachusetts, USA
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Meredith Sweeney
aDepartment of Cell Biology, The Paul F. Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, Massachusetts, USA
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Hong Lu
aDepartment of Cell Biology, The Paul F. Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, Massachusetts, USA
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Thaddeus T. Schug
bLaboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
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Yana Cen
cDepartment of Pharmacology, Weill Medical College of Cornell University, New York, New York, USA
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Seung Min Jeong
aDepartment of Cell Biology, The Paul F. Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, Massachusetts, USA
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Xiaoling Li
bLaboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
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Anthony A. Sauve
cDepartment of Pharmacology, Weill Medical College of Cornell University, New York, New York, USA
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Marcia C. Haigis
aDepartment of Cell Biology, The Paul F. Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, Massachusetts, USA
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DOI: 10.1128/MCB.00087-13
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Article Information

DOI 
https://doi.org/10.1128/MCB.00087-13
PubMed 
24043310

Published By 
American Society for Microbiology Journals
History 
  • Received January 20, 2013
  • Returned for modification February 18, 2013
  • Accepted September 9, 2013
  • Published online October 24, 2013.

Copyright & Usage 
Copyright © 2013, American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (September 16, 2013).
  • You are viewing the most recent version of this article.

Author Information

  1. Gaëlle Laurenta,
  2. Vincent C. J. de Boera*,
  3. Lydia W. S. Finleya,
  4. Meredith Sweeneya,
  5. Hong Lua,
  6. Thaddeus T. Schugb,
  7. Yana Cenc,
  8. Seung Min Jeonga,
  9. Xiaoling Lib,
  10. Anthony A. Sauvec and
  11. Marcia C. Haigisa
  1. aDepartment of Cell Biology, The Paul F. Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, Massachusetts, USA
  2. bLaboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
  3. cDepartment of Pharmacology, Weill Medical College of Cornell University, New York, New York, USA
  • Address correspondence to Marcia C. Haigis, marcia_haigis{at}hms.harvard.edu.
  • ↵* Present address: Vincent C. J. de Boer, Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, The Netherlands.

  • G.L. and V.C.J.D.B. contributed equally to this article.

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SIRT4 Represses Peroxisome Proliferator-Activated Receptor α Activity To Suppress Hepatic Fat Oxidation
Gaëlle Laurent, Vincent C. J. de Boer, Lydia W. S. Finley, Meredith Sweeney, Hong Lu, Thaddeus T. Schug, Yana Cen, Seung Min Jeong, Xiaoling Li, Anthony A. Sauve, Marcia C. Haigis
Molecular and Cellular Biology Oct 2013, 33 (22) 4552-4561; DOI: 10.1128/MCB.00087-13

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SIRT4 Represses Peroxisome Proliferator-Activated Receptor α Activity To Suppress Hepatic Fat Oxidation
Gaëlle Laurent, Vincent C. J. de Boer, Lydia W. S. Finley, Meredith Sweeney, Hong Lu, Thaddeus T. Schug, Yana Cen, Seung Min Jeong, Xiaoling Li, Anthony A. Sauve, Marcia C. Haigis
Molecular and Cellular Biology Oct 2013, 33 (22) 4552-4561; DOI: 10.1128/MCB.00087-13
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