Table of Contents

Articles

• Open Access

  Articles

  Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation

  Rubén García-Martín, Vasileia I. Alexaki, Nan Qin, María F. Rubín de Celis, Matina Economopoulou, Athanasios Ziogas, Bettina Gercken, Klara Kotlabova, Julia Phieler, Monika Ehrhart-Bornstein, Stefan R. Bornstein, Graeme Eisenhofer, Georg Breier, Matthias Blüher, Jochen Hampe, Ali El-Armouche, Antonios Chatzigeorgiou, Kyoung-Jin Chung, Triantafyllos Chavakis
• Articles

  UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4^DDB2-Mediated Degradation To Regulate Cell Proliferation

  Ryoichi Matsunuma, Hiroyuki Niida, Tatsuya Ohhata, Kyoko Kitagawa, Satoshi Sakai, Chiharu Uchida, Bunsyo Shiotani, Masaki Matsumoto, Keiichi I. Nakayama, Hiroyuki Ogura, Norihiko Shiiya, Masatoshi Kitagawa
• Articles

  The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression

  Hiroki Sekine, Keito Okazaki, Nao Ota, Hiroki Shima, Yasutake Katoh, Norio Suzuki, Kazuhiko Igarashi, Mitsuhiro Ito, Hozumi Motohashi, Masayuki Yamamoto
• Articles

  Natural Functions of PLIN2 Mediating Wnt/LiCl Signaling and Glycogen Synthase Kinase 3 (GSK3)/GSK3 Substrate-Related Effects Are Modulated by Lipid

  Xunxian Liu, Xinyue Lu, Kaimei Song, Marc R. Blackman
• Open Access

  Articles

  p53 Restoration in Induction and Maintenance of Senescence: Differential Effects in Premalignant and Malignant Tumor Cells

  Mohamad Harajly, Hasan Zalzali, Zafar Nawaz, Sandra E. Ghayad, Farah Ghamloush, Hussein Basma, Samiha Zainedin, Wissam Rabeh, Mark Jabbour, Ayman Tawil, Danielle A. Badro, Gerard I. Evan, Raya Saab
• Articles

  Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation

  Laura Wiehle, Günter Raddatz, Tanja Musch, Meelad M. Dawlaty, Rudolf Jaenisch, Frank Lyko, Achim Breiling
• Open Access

  Articles

  Essential Nonredundant Function of the Catalytic Activity of Histone Deacetylase 2 in Mouse Development

  Astrid Hagelkruys, Katharina Mattes, Verena Moos, Magdalena Rennmayr, Manuela Ringbauer, Anna Sawicka, Christian Seiser
• Articles | Spotlight

  Binding of the Extracellular Eight-Cysteine Motif of Opy2 to the Putative Osmosensor Msb2 Is Essential for Activation of the Yeast High-Osmolarity Glycerol Pathway

  Katsuyoshi Yamamoto, Kazuo Tatebayashi, Haruo Saito
• Articles

  LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding

  Justin H. Layer, Catherine E. Alford, W. Hayes McDonald, Utpal P. Davé
• Articles

  Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking

  Subramanya N. M. Pandruvada, Janie Beauregard, Suzanne Benjannet, Monica Pata, Claude Lazure, Nabil G. Seidah, Jean Vacher