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Research Article

Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation

Ryota Shizu, Makoto Osabe, Lalith Perera, Rick Moore, Tatsuya Sueyoshi, Masahiko Negishi
Ryota Shizu
aPharmacogenetic Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
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Makoto Osabe
aPharmacogenetic Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
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Lalith Perera
bComputational Chemistry and Molecular Modeling Support Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
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Rick Moore
aPharmacogenetic Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
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Tatsuya Sueyoshi
aPharmacogenetic Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
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Masahiko Negishi
aPharmacogenetic Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
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DOI: 10.1128/MCB.00649-16
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Article Information

DOI 
https://doi.org/10.1128/MCB.00649-16
PubMed 
28265001

Published By 
American Society for Microbiology Journals
History 
  • Received December 12, 2016
  • Returned for modification December 29, 2016
  • Accepted February 18, 2017
  • Published online May 2, 2017.

Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved .

Article Versions

  • Accepted Manuscript version (March 06, 2017).
  • You are viewing the most recent version of this article.

Author Information

  1. Ryota Shizua,
  2. Makoto Osabea*,
  3. Lalith Pererab,
  4. Rick Moorea,
  5. Tatsuya Sueyoshia and
  6. Masahiko Negishia
  1. aPharmacogenetic Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
  2. bComputational Chemistry and Molecular Modeling Support Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
  • Address correspondence to Masahiko Negishi, negishi{at}niehs.nih.gov.
  • Citation Shizu R, Osabe M, Perera L, Moore R, Sueyoshi T, Negishi M. 2017. Phosphorylated nuclear receptor CAR forms a homodimer to repress its constitutive activity for ligand activation. Mol Cell Biol 37:e00649-16. https://doi.org/10.1128/MCB.00649-16 .

  • ↵* Present address: Makoto Osabe, Department of Regulatory Science/Medicinal Safety Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.

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Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation
Ryota Shizu, Makoto Osabe, Lalith Perera, Rick Moore, Tatsuya Sueyoshi, Masahiko Negishi
Molecular and Cellular Biology May 2017, 37 (10) e00649-16; DOI: 10.1128/MCB.00649-16

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Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation
Ryota Shizu, Makoto Osabe, Lalith Perera, Rick Moore, Tatsuya Sueyoshi, Masahiko Negishi
Molecular and Cellular Biology May 2017, 37 (10) e00649-16; DOI: 10.1128/MCB.00649-16
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KEYWORDS

Hepatocytes
Neuropeptides
Protein Phosphatase 2
Receptors, Cytoplasmic and Nuclear
CITCO
cell signaling
constitutive androstane receptor
homodimer
nuclear receptors
phenobarbital
protein phosphorylation

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