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Research Article | Spotlight

Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes

Michael John Kerins, Ajay Amar Vashisht, Benjamin Xi-Tong Liang, Spencer Jordan Duckworth, Brandon John Praslicka, James Akira Wohlschlegel, Aikseng Ooi
Michael John Kerins
aDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA
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Ajay Amar Vashisht
bDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
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Benjamin Xi-Tong Liang
aDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA
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Spencer Jordan Duckworth
aDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA
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Brandon John Praslicka
aDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA
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James Akira Wohlschlegel
bDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
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Aikseng Ooi
aDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA
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DOI: 10.1128/MCB.00079-17
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Article Information

DOI 
https://doi.org/10.1128/MCB.00079-17
PubMed 
28289076

Published By 
American Society for Microbiology Journals
History 
  • Received February 22, 2017
  • Accepted March 7, 2017
  • Published online May 16, 2017.

Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved .

Article Versions

  • Accepted Manuscript version (March 13, 2017).
  • You are viewing the most recent version of this article.

Author Information

  1. Michael John Kerinsa,
  2. Ajay Amar Vashishtb*,
  3. Benjamin Xi-Tong Lianga,
  4. Spencer Jordan Duckwortha,
  5. Brandon John Praslickaa,
  6. James Akira Wohlschlegelb and
  7. Aikseng Ooia
  1. aDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA
  2. bDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
  • Address correspondence to Aikseng Ooi, ooi{at}pharmacy.arizona.edu.
  • Citation Kerins MJ, Vashisht AA, Liang BX-T, Duckworth SJ, Praslicka BJ, Wohlschlegel JA, Ooi A. 2017. Fumarate mediates a chronic proliferative signal in fumarate hydratase-inactivated cancer cells by increasing transcription and translation of ferritin genes. Mol Cell Biol 37:e00079-17. https://doi.org/10.1128/MCB.00079-17 .

  • ↵* Present address: Ajay Amar Vashisht, Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.

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Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes
Michael John Kerins, Ajay Amar Vashisht, Benjamin Xi-Tong Liang, Spencer Jordan Duckworth, Brandon John Praslicka, James Akira Wohlschlegel, Aikseng Ooi
Molecular and Cellular Biology May 2017, 37 (11) e00079-17; DOI: 10.1128/MCB.00079-17

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Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes
Michael John Kerins, Ajay Amar Vashisht, Benjamin Xi-Tong Liang, Spencer Jordan Duckworth, Brandon John Praslicka, James Akira Wohlschlegel, Aikseng Ooi
Molecular and Cellular Biology May 2017, 37 (11) e00079-17; DOI: 10.1128/MCB.00079-17
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KEYWORDS

Carcinoma, Renal Cell
Ferritins
Fumarate Hydratase
Fumarates
Kidney Neoplasms
Leiomyomatosis
Protein Biosynthesis
Transcription, Genetic
ferritin
FH
FOXM1
fumarate
HLRCC
NRF2

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