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Research Article | Spotlight

Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver

Sung E. Choi, Sanghoon Kwon, Sunmi Seok, Zhen Xiao, Kwan-Woo Lee, Yup Kang, Xiaoling Li, Kosaku Shinoda, Shingo Kajimura, Byron Kemper, Jongsook Kim Kemper
Sung E. Choi
aDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
bDepartment of Physiology, Ajou University School of Medicine, Suwon, Kyunggi-do, Republic of Korea
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Sanghoon Kwon
aDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
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Sunmi Seok
aDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
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Zhen Xiao
cLaboratory of Proteomics and Analytical Technologies, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA
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Kwan-Woo Lee
dDepartment of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Kyunggi-do, Republic of Korea
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Yup Kang
bDepartment of Physiology, Ajou University School of Medicine, Suwon, Kyunggi-do, Republic of Korea
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Xiaoling Li
eLaboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
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Kosaku Shinoda
fLaboratory UCSF Diabetes Center and Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California, USA
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Shingo Kajimura
fLaboratory UCSF Diabetes Center and Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California, USA
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Byron Kemper
aDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
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Jongsook Kim Kemper
aDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
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DOI: 10.1128/MCB.00006-17
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Article Information

DOI 
https://doi.org/10.1128/MCB.00006-17
PubMed 
28533219

Published By 
American Society for Microbiology Journals
History 
  • Received January 5, 2017
  • Returned for modification January 28, 2017
  • Accepted May 5, 2017
  • Published online July 14, 2017.

Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved .

Article Versions

  • Accepted Manuscript version (May 22, 2017).
  • You are viewing the most recent version of this article.

Author Information

  1. Sung E. Choia,b,
  2. Sanghoon Kwona,
  3. Sunmi Seoka,
  4. Zhen Xiaoc,
  5. Kwan-Woo Leed,
  6. Yup Kangb,
  7. Xiaoling Lie,
  8. Kosaku Shinodaf,
  9. Shingo Kajimuraf,
  10. Byron Kempera and
  11. Jongsook Kim Kempera
  1. aDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
  2. bDepartment of Physiology, Ajou University School of Medicine, Suwon, Kyunggi-do, Republic of Korea
  3. cLaboratory of Proteomics and Analytical Technologies, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA
  4. dDepartment of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Kyunggi-do, Republic of Korea
  5. eLaboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
  6. fLaboratory UCSF Diabetes Center and Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California, USA
  • Address correspondence to Jongsook Kim Kemper, jongsook{at}illinois.edu.
  • S. E. Choi, S. Kwon, and S. Seok contributed equally to this study.

  • Citation Choi SE, Kwon S, Seok S, Xiao Z, Lee K-W, Kang Y, Li X, Shinoda K, Kajimura S, Kemper B, Kemper JK. 2017. Obesity-linked phosphorylation of SIRT1 by casein kinase 2 inhibits its nuclear localization and promotes fatty liver. Mol Cell Biol 37:e00006-17. https://doi.org/10.1128/MCB.00006-17 .

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Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver
Sung E. Choi, Sanghoon Kwon, Sunmi Seok, Zhen Xiao, Kwan-Woo Lee, Yup Kang, Xiaoling Li, Kosaku Shinoda, Shingo Kajimura, Byron Kemper, Jongsook Kim Kemper
Molecular and Cellular Biology Jul 2017, 37 (15) e00006-17; DOI: 10.1128/MCB.00006-17

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Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver
Sung E. Choi, Sanghoon Kwon, Sunmi Seok, Zhen Xiao, Kwan-Woo Lee, Yup Kang, Xiaoling Li, Kosaku Shinoda, Shingo Kajimura, Byron Kemper, Jongsook Kim Kemper
Molecular and Cellular Biology Jul 2017, 37 (15) e00006-17; DOI: 10.1128/MCB.00006-17
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KEYWORDS

Casein Kinase II
liver
Non-alcoholic Fatty Liver Disease
Sirtuin 1
deacetylase
NAFLD
steatosis
diabetes
fatty acid oxidation
PGC-1alpha
sirtuin

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