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Research Article | Spotlight

Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation

Thorben M. Hummel, Theresa Ackfeld, Marco Schönberg, Gregor Ciupka, Falk Schulz, Anne Oberdoerster, Joachim Grötzinger, Jürgen Scheller, Doreen M. Floss
Thorben M. Hummel
aInstitute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany
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Theresa Ackfeld
aInstitute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany
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Marco Schönberg
aInstitute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany
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Gregor Ciupka
aInstitute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany
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Falk Schulz
aInstitute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany
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Anne Oberdoerster
bInstitute of Biochemistry, Medical Faculty, Christian Albrechts University, Kiel, Germany
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Joachim Grötzinger
bInstitute of Biochemistry, Medical Faculty, Christian Albrechts University, Kiel, Germany
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Jürgen Scheller
aInstitute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany
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Doreen M. Floss
aInstitute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany
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DOI: 10.1128/MCB.00014-17
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Article Information

DOI 
https://doi.org/10.1128/MCB.00014-17
PubMed 
28630278

Published By 
American Society for Microbiology Journals
History 
  • Received January 11, 2017
  • Returned for modification February 10, 2017
  • Accepted May 22, 2017
  • Published online August 11, 2017.

Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved .

Article Versions

  • Accepted Manuscript version (June 19, 2017).
  • You are viewing the most recent version of this article.

Author Information

  1. Thorben M. Hummela,
  2. Theresa Ackfelda,
  3. Marco Schönberga,
  4. Gregor Ciupkaa*,
  5. Falk Schulza,
  6. Anne Oberdoersterb*,
  7. Joachim Grötzingerb,
  8. Jürgen Schellera and
  9. Doreen M. Flossa
  1. aInstitute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany
  2. bInstitute of Biochemistry, Medical Faculty, Christian Albrechts University, Kiel, Germany
  • Address correspondence to Jürgen Scheller, jscheller{at}uni-duesseldorf.de, or Doreen M. Floss, doreen.floss{at}uni-duesseldorf.de.
  • T.M.H. and T.A. contributed equally to this work.

  • Citation Hummel TM, Ackfeld T, Schönberg M, Ciupka G, Schulz F, Oberdoerster A, Grötzinger J, Scheller J, Floss DM. 2017. Synthetic deletion of the interleukin 23 receptor (IL-23R) stalk region led to autonomous IL-23R homodimerization and activation. Mol Cell Biol 37:e00014-17. https://doi.org/10.1128/MCB.00014-17 .

  • ↵* Present address: Gregor Ciupka, Institute of Virology, Universitätsklinikum Düsseldorf, Düsseldorf, Germany; Anne Oberdoerster, Kinder- und Jugendmedizin, Imland Klinik, Rendsburg, Germany.

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Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation
Thorben M. Hummel, Theresa Ackfeld, Marco Schönberg, Gregor Ciupka, Falk Schulz, Anne Oberdoerster, Joachim Grötzinger, Jürgen Scheller, Doreen M. Floss
Molecular and Cellular Biology Aug 2017, 37 (17) e00014-17; DOI: 10.1128/MCB.00014-17

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Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation
Thorben M. Hummel, Theresa Ackfeld, Marco Schönberg, Gregor Ciupka, Falk Schulz, Anne Oberdoerster, Joachim Grötzinger, Jürgen Scheller, Doreen M. Floss
Molecular and Cellular Biology Aug 2017, 37 (17) e00014-17; DOI: 10.1128/MCB.00014-17
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KEYWORDS

Interleukin-23
Protein Multimerization
Receptors, Interleukin
Receptors, Interleukin-12
STAT3 Transcription Factor
Sequence Deletion
IL-23 receptor
IL-23 signaling

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