Table of Contents

Research Articles

• Research Article

  Checkpoint-Independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 Kinase

  Seiji Matsumoto, Yutaka Kanoh, Michie Shimmoto, Motoshi Hayano, Kyosuke Ueda, Rino Fukatsu, Naoko Kakusho, Hisao Masai
• Research Article | Spotlight

  Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling

  Xiaocui Zhang, Geneviève Lavoie, Antoine Méant, Léo Aubert, Marie Cargnello, André Haman, Trang Hoang, Philippe P. Roux
• Research Article

  SETD4 Regulates Cell Quiescence and Catalyzes the Trimethylation of H4K20 during Diapause Formation in Artemia

  Li Dai, Sen Ye, Hua-Wei Li, Dian-Fu Chen, Hong-Liang Wang, Sheng-Nan Jia, Cheng Lin, Jin-Shu Yang, Fan Yang, Hiromichi Nagasawa, Wei-Jun Yang
• Research Article

  Activation-Dependent TRAF3 Exon 8 Alternative Splicing Is Controlled by CELF2 and hnRNP C Binding to an Upstream Intronic Element

  Astrid-Solveig Schultz, Marco Preussner, Mario Bunse, Rotem Karni, Florian Heyd
• Research Article

  KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3

  Emi Sasaki, Koichiro Susa, Takayasu Mori, Kiyoshi Isobe, Yuya Araki, Yuichi Inoue, Yuki Yoshizaki, Fumiaki Ando, Yutaro Mori, Shintaro Mandai, Moko Zeniya, Daiei Takahashi, Naohiro Nomura, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
• Research Article

  D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes

  Amelie Witte, Bernhard Meineke, Jana Sticht, Lars Philipsen, Benno Kuropka, Andreas J. Müller, Christian Freund, Burkhart Schraven, Stefanie Kliche
• Open Access

  Research Article

  A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization

  Lucas J. M. Bruurs, Susan Zwakenberg, Mirjam C. van der Net, Fried J. Zwartkruis, Johannes L. Bos
• Research Article

  HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation

  Lan Liu, Ran Zhuang, Lan Xiao, Hee Kyoung Chung, Jason Luo, Douglas J. Turner, Jaladanki N. Rao, Myriam Gorospe, Jian-Ying Wang
• Open Access

  Research Article | Spotlight

  TOR Complex 2-Regulated Protein Kinase Fpk1 Stimulates Endocytosis via Inhibition of Ark1/Prk1-Related Protein Kinase Akl1 in Saccharomyces cerevisiae

  Françoise M. Roelants, Kristin L. Leskoske, Ross T. A. Pedersen, Alexander Muir, Jeffrey M.-H. Liu, Gregory C. Finnigan, Jeremy Thorner
• Research Article

  mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation

  Stephen Fitter, Mary P. Matthews, Sally K. Martin, Jianling Xie, Soo Siang Ooi, Carl R. Walkley, John D. Codrington, Markus A. Ruegg, Michael N. Hall, Christopher G. Proud, Stan Gronthos, Andrew C. W. Zannettino