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Research Article

HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation

Lan Liu, Ran Zhuang, Lan Xiao, Hee Kyoung Chung, Jason Luo, Douglas J. Turner, Jaladanki N. Rao, Myriam Gorospe, Jian-Ying Wang
Lan Liu
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USABaltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA
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Ran Zhuang
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USABaltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA
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Lan Xiao
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USABaltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA
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Hee Kyoung Chung
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USABaltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA
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Jason Luo
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USABaltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA
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Douglas J. Turner
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USABaltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA
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Jaladanki N. Rao
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USABaltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA
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Myriam Gorospe
Laboratory of Genetics and Genomics, National Institute on Aging-IRP, National Institutes of Health, Baltimore, Maryland, USA
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Jian-Ying Wang
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USABaltimore Veterans Affairs Medical Center, Baltimore, Maryland, USADepartment of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
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DOI: 10.1128/MCB.00574-16
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Article Information

DOI 
https://doi.org/10.1128/MCB.00574-16
PubMed 
28031329

Published By 
American Society for Microbiology Journals
History 
  • Received October 19, 2016
  • Returned for modification November 22, 2016
  • Accepted December 21, 2016
  • Published online March 17, 2017.

Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (December 28, 2016).
  • You are viewing the most recent version of this article.

Author Information

  1. Lan Liua,b,
  2. Ran Zhuanga,b*,
  3. Lan Xiaoa,b,
  4. Hee Kyoung Chunga,b,
  5. Jason Luoa,b,
  6. Douglas J. Turnera,b,
  7. Jaladanki N. Raoa,b,
  8. Myriam Gorospec and
  9. Jian-Ying Wanga,b,d
  1. aCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
  2. bBaltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA
  3. cLaboratory of Genetics and Genomics, National Institute on Aging-IRP, National Institutes of Health, Baltimore, Maryland, USA
  4. dDepartment of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
  • Address correspondence to Jian-Ying Wang, jywang{at}som.umaryland.edu.
  • ↵* Present address: Ran Zhuang, Department of Immunology and Microbiology, Fourth Military Medical University, Xi'an, People's Republic of China.

  • Citation Liu L, Zhuang R, Xiao L, Chung HK, Luo J, Turner DJ, Rao JN, Gorospe M, Wang J-Y. 2017. HuR enhances early restitution of the intestinal epithelium by increasing Cdc42 translation. Mol Cell Biol 37:e00574-16. https://doi.org/10.1128/MCB.00574-16.

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HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation
Lan Liu, Ran Zhuang, Lan Xiao, Hee Kyoung Chung, Jason Luo, Douglas J. Turner, Jaladanki N. Rao, Myriam Gorospe, Jian-Ying Wang
Molecular and Cellular Biology Mar 2017, 37 (7) e00574-16; DOI: 10.1128/MCB.00574-16

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HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation
Lan Liu, Ran Zhuang, Lan Xiao, Hee Kyoung Chung, Jason Luo, Douglas J. Turner, Jaladanki N. Rao, Myriam Gorospe, Jian-Ying Wang
Molecular and Cellular Biology Mar 2017, 37 (7) e00574-16; DOI: 10.1128/MCB.00574-16
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KEYWORDS

gut epithelial restitution
mucosal homeostasis
small GTPases
cell migration
mRNA stability
translation

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