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Research Article

Gs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP Signaling

Dmitry Akhmedov, Maria G. Mendoza-Rodriguez, Kavitha Rajendran, Mario Rossi, Jürgen Wess, Rebecca Berdeaux
Dmitry Akhmedov
aDepartment of Integrative Biology and Pharmacology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA
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Maria G. Mendoza-Rodriguez
aDepartment of Integrative Biology and Pharmacology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA
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Kavitha Rajendran
aDepartment of Integrative Biology and Pharmacology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA
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Mario Rossi
dMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
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Jürgen Wess
dMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
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Rebecca Berdeaux
aDepartment of Integrative Biology and Pharmacology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA
bInstitute of Molecular Medicine Center for Metabolic and Degenerative Diseases, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA
cCell and Regulatory Biology Program of The University of Texas Graduate School of Biomedical Sciences, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA
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  • ORCID record for Rebecca Berdeaux
DOI: 10.1128/MCB.00584-16
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Article Information

DOI 
https://doi.org/10.1128/MCB.00584-16
PubMed 
28167604

Published By 
American Society for Microbiology Journals
History 
  • Received October 26, 2016
  • Returned for modification November 9, 2016
  • Accepted January 29, 2017
  • Published online April 14, 2017.

Copyright & Usage 
Copyright © 2017 Akhmedov et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license .

Article Versions

  • Accepted Manuscript version (February 06, 2017).
  • You are viewing the most recent version of this article.

Author Information

  1. Dmitry Akhmedova,
  2. Maria G. Mendoza-Rodrigueza,
  3. Kavitha Rajendrana,
  4. Mario Rossid,
  5. Jürgen Wessd and
  6. Rebecca Berdeauxa,b,c
  1. aDepartment of Integrative Biology and Pharmacology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA
  2. bInstitute of Molecular Medicine Center for Metabolic and Degenerative Diseases, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA
  3. cCell and Regulatory Biology Program of The University of Texas Graduate School of Biomedical Sciences, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA
  4. dMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
  • Address correspondence to Rebecca Berdeaux, Rebecca.Berdeaux{at}uth.tmc.edu.
  • Citation Akhmedov D, Mendoza-Rodriguez MG, Rajendran K, Rossi M, Wess J, Berdeaux R. 2017. Gs-DREADD knock-in mice for tissue-specific, temporal stimulation of cyclic AMP signaling. Mol Cell Biol 37:e00584-16. https://doi.org/10.1128/MCB.00584-16 .

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Gs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP Signaling
Dmitry Akhmedov, Maria G. Mendoza-Rodriguez, Kavitha Rajendran, Mario Rossi, Jürgen Wess, Rebecca Berdeaux
Molecular and Cellular Biology Apr 2017, 37 (9) e00584-16; DOI: 10.1128/MCB.00584-16

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Gs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP Signaling
Dmitry Akhmedov, Maria G. Mendoza-Rodriguez, Kavitha Rajendran, Mario Rossi, Jürgen Wess, Rebecca Berdeaux
Molecular and Cellular Biology Apr 2017, 37 (9) e00584-16; DOI: 10.1128/MCB.00584-16
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KEYWORDS

cyclic AMP
Hepatocytes
liver
RNA, Untranslated
Receptors, G-Protein-Coupled
CREB
DREADD
GPCR
bioluminescence imaging
cyclic AMP
glucose metabolism
liver

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