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Rescuing Replication from Barriers: Mechanistic Insights from Single-Molecule Studies

Bo Sun
Bo Sun
aSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China
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DOI: 10.1128/MCB.00576-18
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Article Information

DOI 
https://doi.org/10.1128/MCB.00576-18
PubMed 
30886122

Published By 
American Society for Microbiology Journals
History 
  • Published online April 30, 2019.

Copyright & Usage 
Copyright © 2019 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (March 18, 2019).
  • You are viewing the most recent version of this article.

Author Information

  1. Bo Suna
  1. aSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China
  • Address correspondence to sunbo{at}shanghaitech.edu.cn.
  • Citation Sun B. 2019. Rescuing replication from barriers: mechanistic insights from single-molecule studies. Mol Cell Biol 39:e00576-18. https://doi.org/10.1128/MCB.00576-18.

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Rescuing Replication from Barriers: Mechanistic Insights from Single-Molecule Studies
Bo Sun
Molecular and Cellular Biology Apr 2019, 39 (10) e00576-18; DOI: 10.1128/MCB.00576-18

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Rescuing Replication from Barriers: Mechanistic Insights from Single-Molecule Studies
Bo Sun
Molecular and Cellular Biology Apr 2019, 39 (10) e00576-18; DOI: 10.1128/MCB.00576-18
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  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • SINGLE-MOLECULE TECHNIQUES
    • REPLICATIVE HELICASES UNWIND THROUGH OBSTACLES
    • DNAP DIRECTLY SYNTHESIZES THROUGH LESIONS
    • FORK REGRESSION AND REVERSAL PATHWAY
    • LESION SKIPPING AND REPLICATION REINITIATION
    • CONCLUSIONS AND FUTURE OUTLOOK
    • ACKNOWLEDGMENTS
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

bypass
DNA replication
helicase
lesion
magnetic tweezer
obstacle
optical tweezer
polymerase
reactivation
single molecule

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