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Research Article

ZFP281 Recruits MYC to Active Promoters in Regulating Transcriptional Initiation and Elongation

Zhuojuan Luo, Xiaoxu Liu, Hao Xie, Yan Wang, Chengqi Lin
Zhuojuan Luo
School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, ChinaCo-innovation Center of Neuroregeneration, Nantong University, Nantong, China
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Xiaoxu Liu
School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, China
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Hao Xie
School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, China
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Yan Wang
School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, China
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Chengqi Lin
School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, ChinaCo-innovation Center of Neuroregeneration, Nantong University, Nantong, China
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DOI: 10.1128/MCB.00329-19
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ABSTRACT

The roles of the MYC transcription factor in transcriptional regulation have been studied intensively. However, the general mechanism underlying the recruitment of MYC to chromatin is less clear. Here, we found that the Krüppel-like transcription factor ZFP281 plays important roles in recruiting MYC to active promoters in mouse embryonic stem cells. At the genome scale, ZFP281 is broadly associated with MYC, and the depletion of ZFP281 significantly reduces the levels of MYC and RNA polymerase II at the ZFP281- and MYC-cobound genes. Specially, we found that recruitment is required for the regulation of the Lin28a oncogene and pri-let-7 transcription. Our results therefore suggest a major role of ZFP281 in recruiting MYC to chromatin and the integration of ZFP281 and the MYC/LIN28A/Let-7 loop into a multilevel circuit.

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ZFP281 Recruits MYC to Active Promoters in Regulating Transcriptional Initiation and Elongation
Zhuojuan Luo, Xiaoxu Liu, Hao Xie, Yan Wang, Chengqi Lin
Molecular and Cellular Biology Nov 2019, 39 (24) e00329-19; DOI: 10.1128/MCB.00329-19

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ZFP281 Recruits MYC to Active Promoters in Regulating Transcriptional Initiation and Elongation
Zhuojuan Luo, Xiaoxu Liu, Hao Xie, Yan Wang, Chengqi Lin
Molecular and Cellular Biology Nov 2019, 39 (24) e00329-19; DOI: 10.1128/MCB.00329-19
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KEYWORDS

ZFP281
Myc
transcription
LIN28/Let-7

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