Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About MCB
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Molecular and Cellular Biology
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About MCB
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
Research Article | Spotlight

Mutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity

Leixiang Yang, Tanjing Song, Qian Cheng, Lihong Chen, Jiandong Chen
Leixiang Yang
aMolecular Oncology Department, Moffitt Cancer Center, Tampa, Florida, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tanjing Song
aMolecular Oncology Department, Moffitt Cancer Center, Tampa, Florida, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Qian Cheng
aMolecular Oncology Department, Moffitt Cancer Center, Tampa, Florida, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lihong Chen
aMolecular Oncology Department, Moffitt Cancer Center, Tampa, Florida, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jiandong Chen
aMolecular Oncology Department, Moffitt Cancer Center, Tampa, Florida, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1128/MCB.00375-18
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1128/MCB.00375-18
PubMed 
30455251

Published By 
American Society for Microbiology Journals
History 
  • Received July 25, 2018
  • Returned for modification August 30, 2018
  • Accepted November 13, 2018
  • Published online February 4, 2019.

Copyright & Usage 
Copyright © 2019 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (November 19, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. Leixiang Yanga,
  2. Tanjing Songa*,
  3. Qian Chenga,
  4. Lihong Chena and
  5. Jiandong Chena
  1. aMolecular Oncology Department, Moffitt Cancer Center, Tampa, Florida, USA
  • Address correspondence to Jiandong Chen, Jiandong.chen{at}moffitt.org.
  • ↵* Present address: Tanjing Song, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China.

  • L.Y. and T.S. contributed equally to the study.

  • Citation Yang L, Song T, Cheng Q, Chen L, Chen J. 2019. Mutant p53 sequestration of the MDM2 acidic domain inhibits E3 ligase activity. Mol Cell Biol 39:e00375-18. https://doi.org/10.1128/MCB.00375-18.

Article usage

Article usage: November 2018 to April 2021

Rendering graph...
AbstractFullPdf
Nov 2018252042
Dec 2018292023
Jan 2019290320
Feb 20192885897
Mar 2019722523
Apr 2019501413
May 2019601216
Jun 201933198
Jul 201956157
Aug 2019122621
Sep 201933028
Oct 201943624
Nov 201963629
Dec 201909822
Jan 202033321
Feb 202043015
Mar 202013427
Apr 202023927
May 202022614
Jun 202013217
Jul 202013418
Aug 20201208
Sep 20200126
Oct 202014212
Nov 202013420
Dec 20202309
Jan 202112718
Feb 20212158
Mar 202113618
Apr 20211137
PreviousNext
Back to top
Download PDF
Citation Tools
Mutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity
Leixiang Yang, Tanjing Song, Qian Cheng, Lihong Chen, Jiandong Chen
Molecular and Cellular Biology Feb 2019, 39 (4) e00375-18; DOI: 10.1128/MCB.00375-18

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Alerts
Sign In to Email Alerts with your Email Address
Email

Thank you for sharing this Molecular and Cellular Biology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Mutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity
(Your Name) has forwarded a page to you from Molecular and Cellular Biology
(Your Name) thought you would be interested in this article in Molecular and Cellular Biology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Mutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity
Leixiang Yang, Tanjing Song, Qian Cheng, Lihong Chen, Jiandong Chen
Molecular and Cellular Biology Feb 2019, 39 (4) e00375-18; DOI: 10.1128/MCB.00375-18
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • RESULTS
    • DISCUSSION
    • MATERIALS AND METHODS
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

E3 ligase
MDM2
mutant p53
RING domain
acidic domain
conformation
ubiquitination

Related Articles

Cited By...

About

  • About MCB
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #MCBJournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0270-7306; Online ISSN: 1098-5549