Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About MCB
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Molecular and Cellular Biology
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About MCB
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
Research Article | Spotlight

A Circular RNA from the MDM2 Locus Controls Cell Cycle Progression by Suppressing p53 Levels

Ritu Chaudhary, Bruna R. Muys, Ioannis Grammatikakis, Supriyo De, Kotb Abdelmohsen, Xiao Ling Li, Yuelin Zhu, Swapna Vidhur Daulatabad, Dimitrios Tsitsipatis, Paul S. Meltzer, Myriam Gorospe, Sarath Chandra Janga, Ashish Lal
Ritu Chaudhary
aRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bruna R. Muys
aRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ioannis Grammatikakis
aRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Supriyo De
bLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kotb Abdelmohsen
bLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xiao Ling Li
aRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yuelin Zhu
cMolecular Genetics Section, Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Swapna Vidhur Daulatabad
dDepartment of BioHealth Informatics, School of Informatics and Computing, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dimitrios Tsitsipatis
bLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul S. Meltzer
cMolecular Genetics Section, Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Myriam Gorospe
bLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sarath Chandra Janga
dDepartment of BioHealth Informatics, School of Informatics and Computing, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ashish Lal
aRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1128/MCB.00473-19
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1128/MCB.00473-19
PubMed 
32041821

Published By 
American Society for Microbiology Journals
History 
  • Received October 3, 2019
  • Returned for modification October 27, 2019
  • Accepted January 30, 2020
  • Published online April 13, 2020.

Copyright & Usage 
Copyright © 2020 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (February 10, 2020).
  • You are viewing the most recent version of this article.

Author Information

  1. Ritu Chaudharya*,
  2. Bruna R. Muysa,
  3. Ioannis Grammatikakisa,
  4. Supriyo Deb,
  5. Kotb Abdelmohsenb,
  6. Xiao Ling Lia,
  7. Yuelin Zhuc,
  8. Swapna Vidhur Daulatabadd,
  9. Dimitrios Tsitsipatisb,
  10. Paul S. Meltzerc,
  11. Myriam Gorospeb,
  12. Sarath Chandra Jangad and
  13. Ashish Lala
  1. aRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
  2. bLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
  3. cMolecular Genetics Section, Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
  4. dDepartment of BioHealth Informatics, School of Informatics and Computing, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA
  • Address correspondence to Ritu Chaudhary, Ritu.Chaudhary{at}moffitt.org, or Ashish Lal, ashish.lal{at}nih.gov.
  • ↵* Present address: Ritu Chaudhary, Department of Head and Neck-Endocrine Oncology, Moffitt Cancer Center, Tampa, Florida, USA.

  • Ritu Chaudhary, Bruna R. Muys, and Ioannis Grammatikakis contributed equally to this work. Ritu Chaudhary performed most of the initial experiments, Bruna Muys performed experiments and helped in editing the initial submission, and Ioannis Grammatikakis performed majority of the experiments during the revision and edited the text during the revision.

  • Citation Chaudhary R, Muys BR, Grammatikakis I, De S, Abdelmohsen K, Li XL, Zhu Y, Daulatabad SV, Tsitsipatis D, Meltzer PS, Gorospe M, Janga SC, Lal A. 2020. A circular RNA from the MDM2 locus controls cell cycle progression by suppressing p53 levels. Mol Cell Biol 40:e00473-19. https://doi.org/10.1128/MCB.00473-19.

View Abstract

Article usage

Article usage: February 2020 to January 2021

Rendering graph...
AbstractFullPdf
Feb 2020374063
Mar 2020173130
Apr 20205083954
May 20203153041
Jun 2020701217
Jul 2020701718
Aug 2020662020
Sep 202087179
Oct 2020484229
Nov 2020125834
Dec 202076334
Jan 202142421
PreviousNext
Back to top
Download PDF
Citation Tools
A Circular RNA from the MDM2 Locus Controls Cell Cycle Progression by Suppressing p53 Levels
Ritu Chaudhary, Bruna R. Muys, Ioannis Grammatikakis, Supriyo De, Kotb Abdelmohsen, Xiao Ling Li, Yuelin Zhu, Swapna Vidhur Daulatabad, Dimitrios Tsitsipatis, Paul S. Meltzer, Myriam Gorospe, Sarath Chandra Janga, Ashish Lal
Molecular and Cellular Biology Apr 2020, 40 (9) e00473-19; DOI: 10.1128/MCB.00473-19

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Alerts
Sign In to Email Alerts with your Email Address
Email

Thank you for sharing this Molecular and Cellular Biology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
A Circular RNA from the MDM2 Locus Controls Cell Cycle Progression by Suppressing p53 Levels
(Your Name) has forwarded a page to you from Molecular and Cellular Biology
(Your Name) thought you would be interested in this article in Molecular and Cellular Biology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
A Circular RNA from the MDM2 Locus Controls Cell Cycle Progression by Suppressing p53 Levels
Ritu Chaudhary, Bruna R. Muys, Ioannis Grammatikakis, Supriyo De, Kotb Abdelmohsen, Xiao Ling Li, Yuelin Zhu, Swapna Vidhur Daulatabad, Dimitrios Tsitsipatis, Paul S. Meltzer, Myriam Gorospe, Sarath Chandra Janga, Ashish Lal
Molecular and Cellular Biology Apr 2020, 40 (9) e00473-19; DOI: 10.1128/MCB.00473-19
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • RESULTS
    • DISCUSSION
    • MATERIALS AND METHODS
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

circRNA
p53
MDM2
CRC
cell cycle
DNA damage
circular RNA

Related Articles

Cited By...

About

  • About MCB
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #MCBJournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0270-7306; Online ISSN: 1098-5549