Cover photograph: PARIS plays a major role in mitochondrial dysfunction during cardiac hypertrophy. Restoration of mitochondrial health, as shown by interconnected and reticulate structures (green), by knocking down PARIS in H9C2 hypertrophied myocytes is represented by single-cell imaging. The nucleus is shown in blue due to DAPI (4ʹ,6-diamidino-2-phenylindole) staining. (See related article at e00106-20.) (Copyright © 2020 American Society for Microbiology. All Rights Reserved.)