DOI: 10.1128/MCB.00627-20
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History
- Published online March 24, 2021.
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Copyright © 2021 American Society for Microbiology. All Rights Reserved.
Article Versions
- Accepted Manuscript version (February 01, 2021).
- You are viewing the most recent version of this article.
Author Information
- aDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
- bBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
- cHarvard Medical School, Boston, Massachusetts, USA
- dDepartment of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
- Address correspondence to William C. Hahn, william_hahn{at}dfci.harvard.edu.
Citation Kwon JJ, Hahn WC. 2021. A leucine-rich repeat protein provides a SHOC2 the RAS circuit: a structure-function perspective. Mol Cell Biol 41:e00627-20. https://doi.org/10.1128/MCB.00627-20.
Article usage
- Top
- Article
- ABSTRACT
- INTRODUCTION
- SHOC2 DISCOVERY
- SHOC2: A CANONICAL LRR PROTEIN
- THE MRAS/SHOC2/PP1 HOLOPHOSPHATASE
- THE MRAS/RAF1/SHOC2/HUWE1 COMPLEX
- ERBIN/SCRIB: LAP PROTEINS CONTROL SHOC2-MEDIATED MAPK SIGNALING
- NONCANONICAL ROLE OF RPTOR IN MAPK SIGNALING
- SHOC2 PHOSPHORYLATION AND DEGRADATION CONTROL
- SHOC2 IN PI3K-AKT AND MTOR SIGNALING
- THE DYNAMICS OF SHOC2 SUBCELLULAR LOCALIZATION
- SHOC2 IN RAS MUTANT CANCERS
- SHOC2 AS A POTENTIAL THERAPEUTIC TARGET
- FURTHER AREAS OF INTEREST IN SHOC2 BIOLOGY
- ACKNOWLEDGMENTS
- REFERENCES
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