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Research Article

Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule.

H Matsushime, L H Wang, M Shibuya
H Matsushime
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L H Wang
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M Shibuya
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DOI: 10.1128/MCB.6.8.3000
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ABSTRACT

We isolated a human gene (designated c-ros-1) homologous to the v-ros sequence of UR2 sarcoma virus. Ten exons, 1,414 base pairs spanning 26 kilobases, contained a tyrosine kinase domain, a transmembrane domain, and a part of an extracellular domain carrying an N glycosylation site which was not acquired by UR2 sarcoma virus. The predicted structure of c-ros-1 is unique among the src family and clearly distinct from the human insulin receptor.

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Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule.
H Matsushime, L H Wang, M Shibuya
Molecular and Cellular Biology Aug 1986, 6 (8) 3000-3004; DOI: 10.1128/MCB.6.8.3000

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Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule.
H Matsushime, L H Wang, M Shibuya
Molecular and Cellular Biology Aug 1986, 6 (8) 3000-3004; DOI: 10.1128/MCB.6.8.3000
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