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Research Article

Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species.

B Matoskova, F Rorsman, V Svensson, C Betsholtz
B Matoskova
Department of Pathology, University Hospital, Uppsala, Sweden.
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F Rorsman
Department of Pathology, University Hospital, Uppsala, Sweden.
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V Svensson
Department of Pathology, University Hospital, Uppsala, Sweden.
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C Betsholtz
Department of Pathology, University Hospital, Uppsala, Sweden.
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DOI: 10.1128/MCB.9.7.3148
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ABSTRACT

Using a polymerase chain reaction approach, we have analyzed the alternative usage of the platelet-derived growth factor A-chain exon 6 in mRNA from various cell types. The results show that this sequence is utilized in a small fraction of the mRNA molecules in normal as well as transformed cells and that this phenomenon is conserved among mammalian species.

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Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species.
B Matoskova, F Rorsman, V Svensson, C Betsholtz
Molecular and Cellular Biology Jul 1989, 9 (7) 3148-3150; DOI: 10.1128/MCB.9.7.3148

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Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species.
B Matoskova, F Rorsman, V Svensson, C Betsholtz
Molecular and Cellular Biology Jul 1989, 9 (7) 3148-3150; DOI: 10.1128/MCB.9.7.3148
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