TABLE 1.

SIMPL contains a nuclear localization signal

ProteinNLS sequencea
SIMPLKVFITFEVKGKEKKKKHL259
NucleoplasminRPAATKKAGQAKKKKLDK174
N1N2KRKTEEESPLKDKAKKSK554
Human RBKRSAEGSNPPKPLKKLR877
Mouse RBKRSAEGPNPPKPLKNVR870
Human CBP80RRRHSDENDGGQPHKRRK20
Bipartite NLS consensusK/R K/R (10-12 residues), 3 K/R in 5 residues
SIMPLKVFITFEVKGKEKKKKHL259
SV40 T-agbPKKKRKV132
NF-κB p50QRKRQK372
NF-κB p65HRIEEKRKRTYE340
MycPAAKRVKLD328
Monopartite NLS consensusK R/K×R/K
  • a Single-letter amino acid code is used. Bold letters indicate the basic residues of the monopartite and bipartite NLSs.

  • b Simian virus 40 T antigen.