TABLE 1.

Target genes shared by AML1-ETO, PML-RARα, and PLZF-RARα

Category and GenBank accession no.NameRegulationRegulation (fold induction)>2-fold induction by TSA
PMLRARαPLZF-RARαAML1-ETOU937-fusionKasumi-1
Cadherin/catenin/Wnt signaling
    Z68228PlakoglobinInduced4.205.084.62
    L76702Protein phosphatase 2 A B56-deltaInduced5.543.394.16
    AB000895Cadherin FIB1Repressed0.140.060.36+
    AB000896Cadherin FIB2Repressed0.260.070.31
Cell surface/secreted protein/extracellular matrix
    M16279MIC2 mRNA, complete cdsInduced3.722.422.92
    D83782KIAA0199 geneInduced5.593.364.30
    AF008445Phospholipid scramblaseRepressed0.030.030.07
    S76942Dopamine D4 receptorRepressed0.040.470.12+
    Y00787Monocyte-derived neutrophil chemotactic factorRepressed0.110.110.22
    AB098642Semaphorin ERepressed0.130.080.16
    M92302Calcium channel, voltage-gated, beta 1 subunitRepressed0.160.100.04+
    AB98642OsteomodulinRepressed0.170.020.09
    L14561Atpase, Ca2+ transporting, plasma membrane 1Repressed0.210.230.19
    D79206Ryudocan core proteinRepressed0.220.060.13+
    M32578MHC class II HLA-DR beta-1 mRNA (DR2.3)Repressed0.260.170.06
    AF014958Chemokine receptor XRepressed0.280.070.16+
    AF000562Uroplakin IIRepressed0.450.230.32+
Myeloid differentiation
    U32645Myeloid elf-1-like factorRepressed0.220.070.07
    M13207Granu ocyte-macrophage colony-stimulating factor 1Repressed0.290.250.06++
    M97796Helix-loop-helix protein (Id-2)Repressed0.300.420.17
    M26683Gamma interferonRepressed0.360.420.23
Transcription/chromatin/ nuclear proteins
    X73358hAES-1 mRNAInduced61.7754.9554.95
    Z36714Cyclin FInduced30.1320.0714.67
    M31523Human transcription factor (E2A)Induced5.774.164.22
    U65093msg1-related gene 1 (mrg1)Induced2.102.633.26
    X70683SOX-4 proteinInduced2.092.012.48
    U61145Enhancer of zeste homolog 2 (EZH2)Repressed0.240.320.18
    AB000905H4 histoneRepressed0.300.290.28+
    D87673Heat shock transcription factor 4Repressed0.330.040.05++
    X79200SYT-SSX, synovial sarcoma translocation junctionRepressed0.340.430.24+
    Z49825Hepatocyte nuclear factor 4 alphaRepressed0.340.310.29+
Other or unknown function
    D63391Platelet-activating factor acetylhydrolase IB gammaInduced39.5631.3620.04
    D31764KIAA0064 geneInduced6.666.313.91
    M57567ADP-ribosylation factor (hARF5)Induced3.062.172.31
    L36983Dynamin (DNM)Induced3.422.233.08
    D16480Mitochondrial enoyl-coenzyme A hydrataseInduced2.763.422.54
    AB000467RES4-25Repressed0.000.000.01
    AB000466RES4-24CRepressed0.010.010.01
    U60206Stress-responsive serine/threonine kinase Krs-1Repressed0.030.040.04
    AB000450VRK2Repressed0.030.040.10
    U57450EPC-1 geneRepressed0.060.330.33+
    AB000449VRK1Repressed0.080.070.11
    D49818mRNA for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphateRepressed0.090.210.02
    U92015Defective mariner transposon Hsmar2Repressed0.140.100.14++
    D31897Doc2 (double C2)Repressed0.170.070.14
    U87964Putative G-protein (GP-1)Repressed0.180.180.05+
    AB000115Human mRNA expressed in osteoblastRepressed0.180.170.19+
    AB000462SH3 binding protein, clone RES4-23ARepressed0.200.110.12
    K03183Chorionic gonadotropin beta subunitRepressed0.280.050.30+
    AB000409MNK1Repressed0.290.270.38+
    AB002314KIAA0316Repressed0.370.160.17+
    M16750Pim-1 oncogeneRepressed0.440.270.09++